Results 151 to 160 of about 1,183 (224)

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

open access: yesJournal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating   +7 more
wiley   +1 more source

A Randomised Open‐Label Comparison of Dexamphetamine and Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (ADHD): Symptom Response, Adherence and Weight Impact Over 12 Months

open access: yesJournal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Stimulant medications dexamphetamine and methylphenidate are well‐established for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), but few studies directly compare their efficacy. We aimed to compare the therapeutic and adverse effects of immediate‐release formulations of dexamphetamine and methylphenidate during the ...
Alison Poulton   +9 more
wiley   +1 more source

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?

open access: yesJournal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann   +13 more
wiley   +1 more source

Psychometric Properties of the PROMIS Pediatric Sleep Disturbance and Sleep‐Related Impairment Self and Proxy Short Forms in Early Adolescents With and Without ADHD

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT This study evaluated the psychometric properties and psychopathology correlates of the Patient‐Reported Outcome Measurement Information System (PROMIS) Pediatric Sleep Disturbance and Sleep‐related Impairment Self and Proxy Short Forms in early adolescents with and without attention‐deficit/hyperactivity disorder (ADHD).
Stephen P. Becker   +2 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition

open access: yesObesity Reviews, EarlyView.
ABSTRACT Background In 2023 and 2024, research into semaglutide (SEMA), an antiobesity and antidiabetic medication, indicated potential benefits beyond its approved uses, particularly in preventing Alzheimer's disease (AD). This highlights the link between obesity and AD development.
Amene Saghazadeh   +14 more
wiley   +1 more source

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