Results 91 to 100 of about 6,512,302 (308)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

A mass conservative and water storage consistent variable parameter Muskingum-Cunge approach [PDF]

open access: yesHydrology and Earth System Sciences, 2007
The variable parameter Muskingum-Cunge (MC) flood routing approach, together with several variants proposed in the literature, does not fully preserve the mass balance, particularly when dealing with very mild slopes (&lt;10<sup>&minus;3<
E. Todini
doaj  

Variability of Coronal Mass Ejections [PDF]

open access: yesProceedings of the International Astronomical Union, 2004
Coronal mass ejections (CME) from the solar corona are the most spectacular phenomena of solar activity. Solar physicists are tried to relate CME with other forms of solar activities. CMEs are the result of a large scale rearrangement of solar magnetic field and they are often observed as an eruption of twisted magnetic fields from the solar atmosphere.
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Variable-relevance ranking.

open access: yes, 2023
Variable-relevance ranking of top 10 predictors for each machine learning algorithm. (DOCX)
Ryan P. Strum   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Variable thermal conductivity and mass diffusivity effects in a free convective flow of doubly stratified non-darcian porous medium over a vertical plate

open access: yesInternational Journal of Applied Mechanics and Engineering
The research in this article is carried out to study incompressible and unsteady free convective flow on a semi-infinite isothermal vertical plate in a doubly stratified non-Darcian porous media with variable mass diffusivity and variable thermal ...
Suganthi R.K   +4 more
doaj   +1 more source

FLEXURAL VIBRATIONS OF THE VERTICAL ROD VARIABLE SECTION WITH A CONCENTRATED MASS

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2016
Consider bending vibrations of the vertical rod of variable section with a concentrated mass. We study the oscillations excited vector harmonic and random processes with the components of a kinematic and dynamic disturbances. Determine the amplitudes and
M. Kh. Alokova, Kh. P. Kulterbaev
doaj   +1 more source

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