Results 101 to 110 of about 6,512,302 (308)
Mass Spectrometric Detection of Cholesterol Oxidation in Bovine Sperm [PDF]
, 2011 We report on the presence and formation of cholesterol oxidation products (oxysterols) in bovine sperm. Although cholesterol is the most abundant molecule in the membrane of mammalian cells and is easily oxidized, this is the first report on cholesterol ...
Gadella, B.M. +13 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Grappling with variable mass problems
Scilight, 2022 Solving the vertical launch of grappling hooks to find the best approaches for ...
openaire +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AIP Advances, 2018 Galerkin finite element (GFEM) algorithm is implemented to investigate the variable viscosity, variable thermal conductivity and variable mass diffusion coefficient on viscoelasticity and non-Newtonian rheology of Maxwell fluid.
Imran Haider Qureshi +4 more
doaj +1 more source
, 2013 We follow traces of a basic energy-balance equation able to support a precise definition of the mass effect in our model. It might be explained assuming the quantum vacuum similar to a wavy floor constraining the rolling disk in the classical case; but ...
MASTROCINQUE, GIUSEPPE
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Reconstructing spatially variable mass balances from past ice extents by inverse modeling
Journal of Glaciology, 2018 With the conclusion of the Last Glacial Maximum (LGM), about 20 000 years ago, ended the most recent long-lasting cold phase in Earth history. This last glacial advance left a strong observable imprint on the landscape, such as moraines, trimlines and ...
VJERAN VIŠNJEVIĆ +2 more
doaj +1 more source