Results 41 to 50 of about 21,842 (258)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dam-Axis Siting with Improved Adaptive Variable Neighborhood Search Algorithm

Infrastructures
This study investigates upper-reservoir dam-axis siting in pumped-storage hydropower projects, where cut–fill balance and construction cost are critical under complex terrain conditions.
Xianlin Feng, Rui Huang, Lin Xu, Yi Li, Xinyi Liu, Feixiang Zeng, Zhu Wang   +6 more
doaj   +1 more source

Variable Reduction Strategy Integrated Variable Neighborhood Search and NSGA-II Hybrid Algorithm for Emergency Material Scheduling

Complex System Modeling and Simulation, 2023
Developing a reasonable and efficient emergency material scheduling plan is of great significance to decreasing casualties and property losses. Real-world emergency material scheduling (EMS) problems are typically large-scale and possess complex ...
Zhen Shu, Aijuan Song, Guohua Wu, Witold Pedrycz   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A two-phase variable neighborhood search for solving nonlinear optimal control problems [PDF]

Iranian Journal of Numerical Analysis and Optimization, 2015
In this paper, a two-phase algorithm, namely IVNS, is proposed for solving nonlinear optimal control problems. In each phase of the algorithm, we use a variable neighborhood search (VNS), which performs a uniform distribution in the shaking step and the ...
Reza Ghanbari, Aghileh Heydari, Saeed Nezhadhosein   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Hybrid Genetic Algorithm and Parallel Variable Neighborhood Search for Jobshop Scheduling With an Assembly Stage [PDF]

International Journal of Industrial Engineering and Production Research, 2019
In this research a jobshop scheduling problem with an assembly stage is studied. The objective function is to find a schedule which minimizes completion time for all products. At first, a linear model is introduced to express the problem.
Parviz Fattahi, Sanaz Keneshloo, Fatemeh Daneshamooz, samad Ahmadi   +3 more
doaj   +2 more sources

Variable neighborhood search for the linear ordering problem [PDF]

Computers & Operations Research, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Carlos G. García-González, Dionisio Pérez-Brito, Vicente Campos, Rafael Martí   +3 more
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

PLANEJAMENTO DA EXPANSÃO DE SISTEMAS DE TRANSMISSÃO DE ENERGIA ELÉTRICA COM BUSCA EM VIZINHANÇA VARIÁVEL

Colloquium Exactarum, 2010
The static long-term power transmission network expansion planning problem consists in, given an initial configuration and the generation data and demand of the planning horizon, operation limits, costs and investment restrictions, to determine the ...
Silvia Lopes de Sena Taglialenha, Rubén Romero   +1 more
doaj   +1 more source