Results 51 to 60 of about 21,842 (258)

Greedy Optimization Method for Extractive Summarization of Scientific Articles

IEEE Access, 2021
This work presents a method for summarizing scientific articles from the arXive and PubMed datasets using a greedy Extractive Summarization algorithm. We used the approach along with Variable Neighborhood Search (VNS) to learn what is the top-line exists
Iskander Akhmetov, Alexander Gelbukh, Rustam Mussabayev   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Adaptive Variable Neighborhood Search-Based Supply Network Reconfiguration for Robustness Enhancement

Complexity, 2020
Robustness of a supply network highly depends on its structure. Although structural design methods have been proposed to create supply networks with optimal robustness, a real-life supply network can be quite different from these optimal structural ...
Ping Lou, Yuting Chen, Song Gao
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Terrain-Adaptive Global Path Planning Method Based on Bidirectional Variable Neighborhood Search A*

Actuators
To address the issues of low efficiency and non-smooth paths of the A* algorithm in large-scale environments, a terrain-adaptive global path planning method based on Bidirectional Variable Neighborhood Search A* (Terrain-Adaptive Bidirectional Variable ...
Ze Zhang, Ke Liu, Yulong Lei, Yao Fu, Yutong Liu   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Combinatorial GVNS (General Variable Neighborhood Search) Optimization for Dynamic Garbage Collection

Algorithms, 2018
General variable neighborhood search (GVNS) is a well known and widely used metaheuristic for efficiently solving many NP-hard combinatorial optimization problems. We propose a novel extension of the conventional GVNS. Our approach incorporates ideas and
Christos Papalitsas, Panayiotis Karakostas, Theodore Andronikos, Spyros Sioutas, Konstantinos Giannakis   +4 more
doaj   +1 more source

Heuristic approaches for the car sequencing problems with block batches

EURASIP Journal on Wireless Communications and Networking, 2022
Motivated by the practical supply chain management of the automobile industry, we study the car sequencing problem (CSP) that minimizes the conflicts occur when sequentially manufacturing cars on an assembly line.
Yingjie Yu, Xiaochun Lu, Tao Zhao, Minjiao Cheng, Lin Liu, Wenchao Wei   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source