Results 51 to 60 of about 5,119,730 (291)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Variable Reduction Strategy Integrated Variable Neighborhood Search and NSGA-II Hybrid Algorithm for Emergency Material Scheduling

Complex System Modeling and Simulation, 2023
Developing a reasonable and efficient emergency material scheduling plan is of great significance to decreasing casualties and property losses. Real-world emergency material scheduling (EMS) problems are typically large-scale and possess complex ...
Zhen Shu, Aijuan Song, Guohua Wu, Witold Pedrycz   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dam-Axis Siting with Improved Adaptive Variable Neighborhood Search Algorithm

Infrastructures
This study investigates upper-reservoir dam-axis siting in pumped-storage hydropower projects, where cut–fill balance and construction cost are critical under complex terrain conditions.
Xianlin Feng, Rui Huang, Lin Xu, Yi Li, Xinyi Liu, Feixiang Zeng, Zhu Wang   +6 more
doaj   +1 more source

A two-phase variable neighborhood search for solving nonlinear optimal control problems [PDF]

Iranian Journal of Numerical Analysis and Optimization, 2015
In this paper, a two-phase algorithm, namely IVNS, is proposed for solving nonlinear optimal control problems. In each phase of the algorithm, we use a variable neighborhood search (VNS), which performs a uniform distribution in the shaking step and the ...
Reza Ghanbari, Aghileh Heydari, Saeed Nezhadhosein   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Hybrid Genetic Algorithm and Parallel Variable Neighborhood Search for Jobshop Scheduling With an Assembly Stage [PDF]

International Journal of Industrial Engineering and Production Research, 2019
In this research a jobshop scheduling problem with an assembly stage is studied. The objective function is to find a schedule which minimizes completion time for all products. At first, a linear model is introduced to express the problem.
Parviz Fattahi, Sanaz Keneshloo, Fatemeh Daneshamooz, samad Ahmadi   +3 more
doaj   +2 more sources

Variable neighborhood search for the linear ordering problem [PDF]

Computers & Operations Research, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Carlos G. García-González, Dionisio Pérez-Brito, Vicente Campos, Rafael Martí   +3 more
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

PLANEJAMENTO DA EXPANSÃO DE SISTEMAS DE TRANSMISSÃO DE ENERGIA ELÉTRICA COM BUSCA EM VIZINHANÇA VARIÁVEL

Colloquium Exactarum, 2010
The static long-term power transmission network expansion planning problem consists in, given an initial configuration and the generation data and demand of the planning horizon, operation limits, costs and investment restrictions, to determine the ...
Silvia Lopes de Sena Taglialenha, Rubén Romero   +1 more
doaj   +1 more source