Results 71 to 80 of about 5,119,730 (291)

Heuristic approaches for the car sequencing problems with block batches

EURASIP Journal on Wireless Communications and Networking, 2022
Motivated by the practical supply chain management of the automobile industry, we study the car sequencing problem (CSP) that minimizes the conflicts occur when sequentially manufacturing cars on an assembly line.
Yingjie Yu, Xiaochun Lu, Tao Zhao, Minjiao Cheng, Lin Liu, Wenchao Wei   +5 more
doaj   +1 more source

Approximating object based architecture for legacy software written in procedural languages using Variable Neighborhood Search

, 2014
Legacy software, often written in procedural languages, could be a major concern for organizations due to low maintainability. A possible way out could be migrating the software to object oriented architecture, which is easier to maintain due to better ...
Rahman, T., Selim, M., Gias, A.U., Siddik, M.S., Khaled, S.M.   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An efficient General Variable Neighborhood Search for large Travelling Salesman Problem with Time Windows [PDF]

Yugoslav Journal of Operations Research, 2013
General Variable Neighborhood Search (GVNS) is shown to be a powerful and robust methodology for solving travelling salesman and vehicle routing problems.
Mladenović Nenad, Todosijević Raca, Urošević Dragan   +2 more
doaj   +1 more source

A Neighborhood Search for Sequence-dependent Setup Time in Flow Shop Fabrics Making of Textile Industry [PDF]

, 2011
This paper proposes a neighborhood search to solve scheduling for fabrics making in a textile industry. The production process consists of three production stages from spinning, weaving, and dyeing. All stages have one processor.
Totong,, Kurniawan, Bobby, Sumihartati, Atin   +2 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Penerapan Algoritma Variable Neighborhood Search untuk Optimasi Pemilihan Produk Skincare

Jurnal Teknologi dan Sistem Informasi
Pertumbuhan industri skincare di Indonesia mendorong kebutuhan akan sistem pemilihan produk yang mampu membantu konsumen memilih kombinasi produk yang sesuai dengan jenis kulit dan batas anggaran.
Greta Septy Purwiantono, Amalia Utamima
doaj   +1 more source

A New Local Search for Continuous Location Problems [PDF]

, 2013
This paper presents a new local search approach for solving continuous location problems. The main idea is to exploit the relation between the continuous model and its discrete counterpart.
Mladenovic, Nenad, Drezner, Zvi, Brimberg, Jack, Salhi, Said   +3 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source