Results 91 to 100 of about 21,842 (258)

Heterogeneous Vehicle Routing Method Based on Variable Step Multi‑neighborhood Search

Shuju Caiji Yu Chuli
The vehicle routing problem is a classic combinatorial optimization problem that has been proven to be NP‑hard. It is widely applied to the fields of transportation logistics and intelligent manufacturing.
ZHENG Jiyuan, ZHANG Shaobo, WANG Xin, WANG Xiaobo   +3 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

A variable neighborhood search for the last-mile delivery problem during major infectious disease outbreak. [PDF]

Optim Lett, 2022
Jiang L, Zang X, Dong J, Liang C, Mladenovic N.   +4 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Critical-Path-Based Variable Neighborhood Descent for the Joint Scheduling of FJSP and AGVs

Mathematics
This study addresses the joint scheduling problem of flexible job shop scheduling and automated guided vehicles with the objective of minimizing the makespan.
Han Jia, Yaming Chen, Qian Tian, Dazhi Pan, Yan Yang   +4 more
doaj   +1 more source

A Multi-Neighborhood Multi-Operator Algorithm for the Uncapacitated Exam Proximity Problem [PDF]

Journal of Systemics, Cybernetics and Informatics, 2015
An algorithm featuring multiple local search operators and multiple neighborhood structures is applied to the uncapacitated exam proximity problem. The use of multiplicity is to enable effective interplay between intensification and diversification ...
Tony Wong, Salah Assal
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Variable Neighborhood Search for Multi-Port Berth Allocation with Vessel Speed Optimization

Journal of Marine Science and Engineering
This paper delves into the multi-port berth allocation problem (MBAP), enriching the traditional berth allocation problem (BAP) with vessel speed optimization (VSO).
Yalong Song, Bin Ji, Samson S. Yu
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source