Results 81 to 90 of about 5,119,730 (291)

Hybrid Variable Neighborhood HyperHeuristics for Exam Timetabling Problems [PDF]

, 2005
This paper presents our work on analysing the high level search within a graph based hyperheuristic. The graph based hyperheuristic solves the problem at a higher level by searching through permutations of graph heuristics rather than the actual ...
Burke, Edmund, Qu, Rong
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A general framework for nested variable neighborhood search

Electronic Notes in Discrete Mathematics, 2017
Abstract In this paper we review a recently proposed variant of variable neighborhood search (VNS) referred to as nested variable neighborhood search (NVNS) and propose a generalization of this approach. In addition, we develop a heuristic stemming from this general framework and apply it on the capacitated clustering problem (CCP). Based on obtained
Jack Brimberg, Nenad Mladenovic, Raca Todosijevic, Dragan Urosevic   +3 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

New variants of variable neighbourhood search for 0-1 mixed integer programming and clustering [PDF]

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Many real-world optimisation problems are discrete in nature.
Lazić, Jasmina
core   +4 more sources

An Efficient Variable Neighborhood Search for Solving Multi-Criteria Project Portfolio Selection [PDF]

Control and Optimization in Applied Mathematics
Project portfolio selection is a critical challenge for many organizations as they often face budget constraints that limit their ability to support all available projects. To address this issue, organizations seek to select a feasible subset of projects
Ali Akbar Sohrabi, Reza Ghanbari, Khatere Ghorbani-Moghadam   +2 more
doaj   +1 more source

Variable neighborhood search for solving the balanced location problem

, 2012
In this paper we propose a general variable neighborhood search approach for the balanced location problem. Next to large shaking neighborhoods, the embedded variable neighborhood descent utilizes three neighborhood structures that focus on different ...
Leitner, Markus, Kratica, Jozef, Ljubic, Ivana   +2 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Solving Medium to Large Sized Euclidean Generalized Minimum Spanning Tree Problems [PDF]

The generalized minimum spanning tree problem is a generalization of the minimum spanning tree problem. This network design problems finds several practical applications, especially when one considers the design of a large-capacity backbone network ...
Ghosh, Diptesh
core