Results 61 to 70 of about 5,119,730 (291)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Complexity, 2020 Robustness of a supply network highly depends on its structure. Although structural design methods have been proposed to create supply networks with optimal robustness, a real-life supply network can be quite different from these optimal structural ...
Ping Lou, Yuting Chen, Song Gao
doaj +1 more source
An oil pipeline design problem [PDF]
, 2003 Copyright @ 2003 INFORMSWe consider a given set of offshore platforms and onshore wells producing known (or estimated) amounts of oil to be connected to a port.
Brimberg, J +6 more
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Solving the unconstrained optimization problem by a variable neighborhood search
, 2007 This paper presents variable neighborhood search (VNS) for the problem of finding the global minimum of a nonconvex function. The variable neighborhood search, which changes systematically neighborhood structures in the search for finding a better ...
M. Duran Toksarı +4 more
core +1 more source
EURO Mini Conference (MEC XXVIII) on Variable Neighborhood Search [PDF]
, 2012 We are presenting in this volume selected, peer-reviewed, short papers that were presented at the EURO Mini Conference XXVIII on Variable Neighborhood Search (MEC XXVIII - VNS) which was held during October 4–7, 2012, in Herceg Novi, Montenegro ...
Urošević, Dragan +2 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Terrain-Adaptive Global Path Planning Method Based on Bidirectional Variable Neighborhood Search A*
ActuatorsTo address the issues of low efficiency and non-smooth paths of the A* algorithm in large-scale environments, a terrain-adaptive global path planning method based on Bidirectional Variable Neighborhood Search A* (Terrain-Adaptive Bidirectional Variable ...
Ze Zhang +4 more
doaj +1 more source
Algorithms, 2018 General variable neighborhood search (GVNS) is a well known and widely used metaheuristic for efficiently solving many NP-hard combinatorial optimization problems. We propose a novel extension of the conventional GVNS. Our approach incorporates ideas and
Christos Papalitsas +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source