Results 151 to 160 of about 5,591,095 (382)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

The Magnetic Variable Stars [PDF]

open access: yesInternational Astronomical Union Colloquium, 1976
The peculiar A stars were first noted as peculiar because they exhibit anomalously strong lines of one or more of the elements Si, Cr, Mn, Sr, and Eu. These diverse objects are all called Ap stars because their assigned spectral types fall predominantly in the range B9-F0.
openaire   +2 more sources

Using Machine Learning Method for Variable Star Classification Using the TESS Sectors 1–57 Data

open access: yesThe Astrophysical Journal
The Transiting Exoplanet Survey Satellite is a wide-field all-sky survey mission designed to detect Earth-sized exoplanets. After over 4 yr of photometric surveys, data from sectors 1–57, including approximately 1,050,000 light curves with a 2 minute ...
Li-Heng Wang   +4 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

The variability of T Tauri stars [PDF]

open access: yesSymposium - International Astronomical Union, 1990
For many years we have monitored the variability of some bright T Tauri stars with the 0.6 m “Perkin telescope” at Van Vleck Observatory. Collaborators in this endeavor have included several astronomers at the Crimea Astrophysical Observatory, at Capidomonte Observatory, at the U.S. Naval Observatory, and even some sophisticated amateurs.
openaire   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

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