Results 41 to 50 of about 246,272 (261)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Elastic Curves With Variable Bending Stiffness

Studies in Applied Mathematics
ABSTRACTWe study stationary points of the bending energy of curves subject to constraints on the arc length and the curve's holonomy while simultaneously allowing for a variable bending stiffness along the arc length of the curve. Physically, this can be understood as a model for an elastic wire with isotropic cross section of varying thickness.
Gross, Oliver, Pinkall, Ulrich, Wahl, Moritz   +2 more
openaire   +3 more sources

A NASTRAN DMAP alter for determining a local stiffness modification to obtain a specified eigenvalue [PDF]

, 1973
A technique is described which has been programmed as a DMAP Alter to Rigid Format 3, for determining a stiffness matrix modification to obtain a specified eigenvalue for a structure.
Case, W. R., Jr.
core   +1 more source

Optic nerve head segmentation [PDF]

, 2004
Reliable and efficient optic disk localization and segmentation are important tasks in automated retinal screening. General-purpose edge detection algorithms often fail to segment the optic disk due to fuzzy boundaries, inconsistent image contrast or ...
Basu, A., Fletcher, E., Hunter, Andrew, Kennedy, L., Lowell, J., Ryder, R., Steel, D.   +6 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Variable stiffness polymeric damper [PDF]

, 1969
Shock and vibration damping device using temperature sensitive solid amorphous ...
Lohr, J. J.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Variable Stiffness Actuators: A Port-Based Power-Flow Analysis

IEEE Transactions on Robotics, 2012
Variable stiffness actuators realize a novel class of actuators, which are capable of changing the apparent output stiffness independently of the output position. This is mechanically achieved by the internal introduction of a number of elastic elements and a number of actuated degrees of freedom (DOFs), which determine how the elastic elements are ...
Carloni, Raffaella, Visser, Ludo C., Stramigioli, Stefano   +2 more
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Does the variable-stiffness colonoscope makes colonoscopy easier? A meta-analysis of the efficacy of the variable stiffness colonoscope compared with the standard adult colonoscope

BMC Gastroenterology, 2012
Background The variable-stiffness colonoscope (VSC) appears to have advantages over the standard adult colonoscope (SAC), although data are conflicting. To provide a comprehensive up-to-date review, we conducted a meta-analysis to compare the efficacies ...
Xie Qin, Chen Bin, Liu Liu, Gan Huatian
doaj   +1 more source