Results 51 to 60 of about 4,239,690 (235)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stretched flow of Oldroyd-B fluid with Cattaneo-Christov heat flux

Results in Physics, 2017
The objective of present attempt is to analyse the flow and heat transfer in the flow of an Oldroyd-B fluid over a non-linear stretching sheet having variable thickness.
T. Hayat, M. Waleed Ahmed Khan, A. Alsaedi, M. Ayub, M. Ijaz Khan   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Unsteady Heat and Mass Transfer MHD Flow of Nano-Fluids with Buoyancy and Variable Thermal Conductivity

, 2023
: Scientists and engineers have conducted a considerable lot of experimental and theoretical study to increase the productivity of industrial operations.
Akindele M. Okedoye, Azeez A. Waheed, Olufemi. A. Akinyemi   +2 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

On doubly stratified chemically reactive flow of Powell–Eyring liquid subject to non-Fourier heat flux theory

Results in Physics, 2017
This investigation addresses the chemical reaction and double stratification effects in the flow induced by a nonlinear stretching surface with variable thickness.
T. Hayat, M. Zubair, M. Waqas, A. Alsaedi, M. Ayub   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Dimensioning of Boreholes for Geothermal Heat Pumps [PDF]

Acta Montanistica Slovaca, 2004
The paper deals with determination of borehole depths for geothermal heat pumps. Basic formulae are stated for heat convection in rocks. Software EED 2.0 was used for calculation of borehole depth depending on different entering parameters.
Ryška Jiøí
doaj  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

An unsteady squeezed flow of a tangent hyperbolic fluid over a sensor surface in the presence of variable thermal conductivity

Results in Physics, 2017
The paper explores the numerical study on squeezed flow of tangent hyperbolic fluid over a sensor surface with variable thermal conductivity. The governing equations are reassembling into ordinary non-linear differential equations by using suitable ...
K. Ganesh Kumar, B.J. Gireesha, M.R. Krishanamurthy, N.G. Rudraswamy   +3 more
doaj   +1 more source