Results 71 to 80 of about 4,239,690 (235)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Investigation of double diffusion Cattaneo-Christov model in mixed convection flow by variable thickness surface

Results in Physics, 2017
This investigation examines the characteristics of nonlinear mixed convection flow by stretching sheet with variable thickness. Double diffusion Cattaneo-Christov heat flux model is implemented.
Tasawar Hayat, Zeenat Bashir, Sumaira Qayyum, Ahmed Alsaedi   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Assessment of Soil Thermal Conductivity Based on BPNN Optimized by Genetic Algorithm

Advances in Civil Engineering, 2020
Thermal conductivity is a critical parameter playing an important role in the heat transfer process in thermal engineering and enormous other engineering fields.
Chenyang Liu, Xinmin Hu, Ren Yao, Yalu Han, Yong Wang, Wentong He, Huabin Fan, Lizhi Du   +7 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Magnetohydrodynamics stagnation point flow of tangent hyperbolic fluid over a non-flat rotating disk in intuitionistic fuzzy environment

Journal of Ocean Engineering and Science
An analysis is performed for the three-dimensional stagnation point flow of magnetized tangent hyperbolic fluid over a rotating disk of variable thickness.
Priya Bartwal, B.P. Joshi, Himanshu Upreti, Alok Kumar Pandey, Dharmendra Tripathi   +4 more
doaj   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Thermal quadrupole method with internal heat sources [PDF]

, 2012
A new method based on the thermal quadrupoles technique for heat transfer modelling in multilayered slabs with heat sources is proposed. Classical thermal quadrupoles use hyperbolic functions and numerical problems occur according to the argument value ...
A. Kusiak, BATTAGLIA, Jean-Luc, PRADERE, Christophe, KUSIAK, Andrzej, PAILHES, Jerome, Batsale, J.-C., AREGBA, Aworou Waste, A.W. Aregba, TOUTAIN, Jerome, Aregba, A.W., AREGBA, Waste, J.-C. Batsale, C. Pradere, Kusiak, A., TOUTAIN, Jean, J. Toutain, J. Pailhes, Toutain, J., Pailhes, J., BATSALE, Jean-Christophe, Battaglia, J.-L., J.-L. Battaglia   +21 more
core   +1 more source