FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Investigating the impact of non-additive genetic effects in the estimation of variance components and genomic predictions for heat tolerance and performance traits in crossbred and purebred pig populations. [PDF]
BMC Genom Data, 2023 de Oliveira LF +7 more
europepmc +1 more source
Efficient Estimation of an Additive Quantile Regression Model [PDF]
In this paper two kernel-based nonparametric estimators are proposed for estimating the components of an additive quantile regression model. The first estimator is a computationally convenient approach which can be viewed as a viable alternative to the ...
Cheng, Yebin +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Which method is optimal for estimating variance components and their variability in generalizability theory? evidence form a set of unified rules for bootstrap method. [PDF]
PLoS One, 2023 Li G.
europepmc +1 more source
World Income Components: Measuring and Exploiting International Risk Sharing Opportunities [PDF]
We provide methods of decomposing the variance of world national incomes into components in such a way as to indicate the most important risk-sharing opportunities, and, therefore, the most important missing international risk markets to establish.
Robert J. Shiller +1 more
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Heritability and variance components of seed size in wild species: influences of breeding design and the number of genotypes tested. [PDF]
Heredity (Edinb), 2023 Larios E, Ramirez-Parada TH, Mazer SJ.
europepmc +1 more source
Variances of Variance Components: I. Balanced Designs
The Annals of Mathematical Statistics, 1956 1. Summary. Analyses of variance are sometimes intended to reveal information about means (when tests of significance and, better, confidence procedures are appropriate). At other times analyses of variance have the purpose indicated by their name: to estimate the sizes of the various components contributed to the over-all variance from the ...
openaire +2 more sources