Results 41 to 50 of about 2,210,403 (291)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Conductance fluctuations in the presence of spin scattering [PDF]

, 2003
Electron transport through disordered systems that include spin scatterers is studied numerically. We consider three kinds of magnetic impurities: the Ising, the XY and the Heisenberg. By extending the transfer matrix method to include the spin degree of
B.I. Halperin, B.L. Altshuler, C.W.J. Beenakker, I.K. Marmorkos, I.L. Aleiner, I.L. Aleiner, J. Ohe, J.A. Folk, J.B. Pendry, Jun-ichiro Ohe, M. Büttiker, M. Büttiker, M. Cieplak, M. Cieplak, M. Yamamoto, Masayuki Yamamoto, N.O. Birge, P. Bruno, P. Debray, P.A. Lee, R. Landauer, R. Landauer, S. Datta, T. Ando, T. Koga, T. Matsuyama, Tomi Ohtsuki, Y. Takane   +27 more
core   +1 more source

Analysis of variance components for genetic markers with unphased genotypes

Frontiers in Genetics, 2016
An ANOVA type general multi-allele (GMA) model was proposed in cite{Wang2014} on analysis of variance components for quantitative trait loci or genetic markers with phased or unphased genotypes.
Tao Wang
doaj   +1 more source

Implications of genotype by environment interactions on heritability estimate and variance components of cotton (Gossypium hirsutum L.)

Cogent Food & Agriculture, 2022
Genetic variation in cotton is crucial when traits are heritable and elucidation of the underlying genetic components of these helps in selecting elite genotypes.
Blessing Chapepa, Marco Mare, Washington Mubvekeri, Dumisani Kutywayo   +3 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

PRINCIPAL COMPONENTS TO OVERCOME MULTICOLLINEARITY PROBLEM [PDF]

Oradea Journal of Business and Economics, 2019
The impact of ignoring collinearity among predictors is well documented in a statistical literature. An attempt has been made in this study to document application of Principal components as remedial solution to this problem.
Abubakari S.Gwelo
doaj  

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Estimation models of variance components for farrowing interval in swine

Brazilian Archives of Biology and Technology, 2009
The main objective of this study was to evaluate the importance of including maternal genetic, common litter environmental and permanent environmental effects in estimation models of variance components for the farrowing interval trait in swine.
Aderbal Cavalcante Neto, Jeffrey Frederico Lui, José Lindenberg Rocha Sarmento, Maria Norma Ribeiro, José Mauro Costa Monteiro, Carlos Fonseca, Humberto Tonhati   +6 more
doaj   +1 more source

Estimating Variance Components of Binomial Frequencies [PDF]

, 1971
16 pages, 1 article*Estimating Variance Components of Binomial Frequencies* (Searle, S. R.; Gates, C.
Cornell University. Biometrics Unit., Cornell University. Dept. of Biological Statistics and Computational Biology., Cornell University. Dept. of Biometrics., Gates, C. E., Searle, S. R.   +4 more
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