Results 61 to 70 of about 1,548,550 (297)

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Genomic variant classifier tool

, 2018
The exome or genome based high throughput screening techniques are becoming a definitive criterion in the conventional clinical analysis of the genetic diseases.
Manderick, B., Nowe, A., Van Dooren, S., Bonduelle, M., Garcia Lorenzo, M.M., Farid, D.M., Croes, D., Sengupta, D., Grau, I., Daneels, D.   +9 more
core   +2 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Reactive oxygen species regulation of ferroptosis, autophagy, apoptosis, and immunogenic cell death in cancer

Frontiers in Physiology
Reactive oxygen species (ROS) are produced during metabolism through mitochondrial oxidative phosphorylation and NADPH oxidase activity. In cancer, ROS exhibit a paradoxical, concentration-dependent dual role. At low to moderate levels, ROS promote tumor
Seema Kumari, Sudhir Kumar Rai
doaj   +1 more source

Association between deleterious-variant-containing genes and clinical outcomes in the Hong Kong cohort.

, 2022
(A) Risk of deleterious-variant-containing genes based on clinical characteristics (metastasis and castration resistance within one year) were calculated.
Yonghao Liang (3933299), Qin Cao (802896), Jeremy Yuen-Chun Teoh (10408316), Yu Wei (365236), Yao Zhu (441601), Qing Xiong (136442), Stephen Kwok-Wing Tsui (9358976), Yim-Ping Wong (13775411), Peter Ka-Fung Chiu (12514172), Ding-Wei Ye (104627), Lin Wang (11986), Chi-Fai Ng (3105801)   +11 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Association between deleterious-variant-containing genes and clinical outcomes in the Shanghai cohort.

, 2022
(A) Risk of deleterious-variant-containing based on clinical characteristics (metastasis and castration resistance within one year) were calculated.
Yonghao Liang (3933299), Qin Cao (802896), Jeremy Yuen-Chun Teoh (10408316), Yu Wei (365236), Yao Zhu (441601), Qing Xiong (136442), Stephen Kwok-Wing Tsui (9358976), Yim-Ping Wong (13775411), Peter Ka-Fung Chiu (12514172), Ding-Wei Ye (104627), Lin Wang (11986), Chi-Fai Ng (3105801)   +11 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Single Amino Acid Mutations Affect Zika Virus Replication In Vitro and Virulence In Vivo

Viruses, 2020
The 2014–2016 Zika virus (ZIKV) epidemic in the Americas resulted in large deposits of next-generation sequencing data from clinical samples. This resource was mined to identify emerging mutations and trends in mutations as the outbreak progressed over ...
Nicole M. Collette, Victoria H. I. Lao, Dina R. Weilhammer, Barbara Zingg, Shoshana D. Cohen, Mona Hwang, Lark L. Coffey, Sarah L. Grady, Adam T. Zemla, Monica K. Borucki   +9 more
doaj   +1 more source