Results 51 to 60 of about 1,548,550 (297)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Faroese whole genomes provide insight into ancestry and recent selection

eLife
The Faroe Islands are home to descendants of a North Atlantic founder population with a unique history shaped by both migration and periods of relative isolation.
Iman Hamid, Ólavur Mortensen, Alba Refoyo-Martínez, Leivur N Lydersen, Anne-Katrin Emde, Melissa Hendershott, Katrin D Apol, Guðrið Andorsdóttir, Jonas Meisner, Kaja A Wasik, Fernando Racimo, Stephane E Castel, Noomi O Gregersen   +12 more
doaj   +1 more source

Characterization of a novel COL10A1 variant associated with Schmid‐type metaphyseal chondrodysplasia and a literature review

Molecular Genetics & Genomic Medicine, 2021
Background Schmid‐type metaphyseal chondrodysplasia (SMCD) is a rare autosomal dominant skeletal dysplasia caused by heterozygous mutations in COL10A1, the gene which encodes collagen type X alpha 1 chain. However, its genotype–phenotype relationship has
Huixiao Wu, Shuping Wang, Guimei Li, Yangyang Yao, Ning Wang, Xiaoqing Sun, Li Fang, Xiuyun Jiang, Jiajun Zhao, Yanzhou Wang, Chao Xu   +10 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Bioassay studies support the potential for iatrogenic transmission of variant Creutzfeldt Jakob Disease through dental procedures [PDF]

, 2012
<p>Background: Evidence is required to quantify the potential risks of transmission of variant Creutzfeldt Jakob (vCJD) through dental procedures. Studies, using animal models relevant to vCJD, were performed to address two questions.
Elizabeth Kirby (115076), Marsh, PD, Raven, N.D.H., Mark Cornwall, Andrew Smith (11197), Marsh Philip D., Vassey, M., Neil McLeod (115085), Cornwall Mark, Joanne Dickinson (115078), J. Mark Sutton (115091), Cornwall, M, Dickinson, J., Dickinson Joanne, Vassey Matthew, Mark Cornwall (115083), Raven, NDH, Matthew Vassey (115080), Mike Dennis, Walker, J.T., Kirby Elizabeth, Smith, A, McLeod, N., J Mark Sutton, Walker, JT, Dennis, M., Sutton, J.M., Matthew Vassey, Philip D. Marsh (115087), James T Walker, Marsh, P.D., Dennis, M, Joanne Dickinson, McLeod Neil, McLeod, N, Andrew Smith, Walker James T., Elizabeth Kirby, Raven Neil D. H., Smith, A., Vassey, M, Neil D. H. Raven (115095), James T. Walker (115089), Dickinson, J, Sutton, JM, Sutton J. Mark, Kirby, E, Kirby, E., Smith Andrew, Neil McLeod, Cornwall, M., Mike Dennis (115082), Philip D Marsh, Neil D H Raven, Dennis Mike   +54 more
core   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Vitamin D status in Faroese adults and its association with inflammatory bowel diseases - a cross-sectional study from the FarGen 2 project

International Journal of Circumpolar Health
Vitamin D is vital for physiological functions and is obtained primarily through sunlight and a few dietary sources. With limited sunlight exposure, the Faroe Islands face challenges in maintaining sufficient levels of vitamin D, while the Faroese ...
Randi Næss Lisberg, Kári Rubek Nielsen, Leivur Nattestad Lydersen, Katrin Didriksen Apol, Jóngerð Midjord, Olivia Gray, Melissa Hendershott, Marin Strøm, Noomi Oddmarsdóttir Gregersen   +8 more
doaj   +1 more source

Système graphique et communauté des « professionnels de l’écrit ».

Corela, 2018
Since the end of the 13th century and what Bertrand (2015) calls the “watershed” of 1300, the West has witnessed a remarquable diffusion of the knowledge of legal writing.
Isabelle Bretthauer
doaj   +1 more source

Utility of next-generation sequencing in the diagnosis of neurological disorders

Saudi Journal for Health Sciences, 2023
Background: The spectrum of neurological diseases encompasses a large number of disorders, including neuromuscular disorder (NMDs), ataxias, and muscular dystrophies.
Adnan Firdous Raina, Sana Ahuja, Sushil Razdan, Adil Aziz Khan, Murtaza Habib   +4 more
doaj   +1 more source

Dental treatment and risk of variant CJD - a case control study [PDF]

, 2007
Objective: Knowledge of risk factors for variant CJD (vCJD) remains limited, but transmission of prion proteins via re-useable medical devices, including dental instruments, or enhanced susceptibility following trauma to the oral cavity is a concern ...
Everington, D., S. Letters, J. Bagg, Bagg, J., D. Everington, R. G. Will, Smith, A.J., Letters, S., Will, R.G., Ward, H.J.T., A. J. Smith, H. J. T. Ward   +11 more
core   +1 more source