Results 111 to 120 of about 3,099,093 (291)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

AAV-p40 Bioengineering Platform for Variant Selection Based on Transgene Expression. [PDF]

Hum Gene Ther, 2022
Westhaus A, Cabanes-Creus M, Jonker T, Sallard E, Navarro RG, Zhu E, Baltazar Torres G, Lee S, Wilmott P, Gonzalez-Cordero A, Santilli G, Thrasher AJ, Alexander IE, Lisowski L.   +13 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

GeVaCT - Genomic Variant Classifier Tool

, 2016
High throughput screening (HTS) techniques, like mendeliome, whole exomeand genome screening, are becoming a routine in a clinical diagnosticsetting. However, classifying the identified genomic variants as benign or(likely) pathogenic, is still a tedious
Farid, D., Bonduelle, M.L., Nowé, A., Van Dooren, S., Croes, D., Sengupta, D., Daneels, D., Grau, I.   +7 more
core   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effect of the cooling rate in the medium temperature zone on the phase transformation and microstructure of carbide-free bainitic steel

Journal of Materials Research and Technology
Controlling continuous cooling is considered an effective means of producing high-strength and high-toughness bainitic steel. A medium carbon bainite frog steel is designed.
Xiaoyan Long, Wei Liu, Ranran Zhu, Yu Zhang, Fucheng Zhang, Zhinan Yang, Yanguo Li   +6 more
doaj   +1 more source

Effect of processing parameters on texture and variant selection of as-built 300 maraging steel processed by laser powder bed fusion. [PDF]

Sci Rep, 2022
Eres-Castellanos A, Santana A, De-Castro D, Jimenez JA, Rementeria R, Capdevila C, Caballero FG.   +6 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

'A very complicated version of freedom': Conditions and experiences of creative labour in three cultural industries

, 2011
Full ...
Baker, Sarah, Hesmondhalgh, D.
core