Results 121 to 130 of about 3,099,093 (291)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Crystallographic characteristics of acicular ferrite nucleated on inclusions in a HSLA steel

Journal of Materials Research and Technology
Acicular ferrite (AF) has been regarded as the optimal microstructure in steel welds and heat affect zones (HAZs), because of its superior combination of strength and toughness.
Haitao Zhao, Junheng Gao, Guilin Wu, Honghui Wu, Chaolei Zhang, Yuhe Huang, Yang Luo, Xiaoqian Yang, Shuize Wang   +8 more
doaj   +1 more source

Optimizing and Automating Product-Line Variant Selection for Mobile Devices

, 2007
—Product-line architectures (PLAs) designed for mobile devices create a unique challenge for automated product variant selection engines since variants must be derived on-the-fly as devices are discovered. Current automation techniques do not incorporate
Doulas C. Schmidt, Jules White
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Variant Selection and Interpretation: An Example of Modified VarSome Classifier of ACMG Guidelines in the Diagnostic Setting. [PDF]

Genes (Basel), 2021
Cristofoli F, Sorrentino E, Guerri G, Miotto R, Romanelli R, Zulian A, Cecchin S, Paolacci S, Miertus J, Bertelli M, Maltese PE, Chiurazzi P, Stuppia L, Castori M, Marceddu G.   +14 more
europepmc   +1 more source

GEVACT: Genomic Variant Classifier Tool

, 2015
High throughput screening (HTS) techniques, like mendeliome, whole exomeand genome screening, are becoming a routine in a clinical diagnosticsetting. However, classifying the identified genomic variants as benign or(likely) pathogenic, is still a tedious
Farid, D., Bonduelle, M.L., Nowé, A., Van Dooren, S., Bonduelle, M., Farid, D.M., Croes, D., Bonduelle , M., Sengupta, D., Daneels, D., Grau, I.   +10 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.

PLoS Pathogens
SARS-CoV-2 has undergone repeated and rapid evolution to circumvent host immunity. However, outside of prolonged infections in immunocompromised hosts, within-host positive selection has rarely been detected.
Emily E Bendall, Derek Dimcheff, Leigh Papalambros, William J Fitzsimmons, Yuwei Zhu, Jonathan Schmitz, Natasha Halasa, James Chappell, Emily T Martin, Jessica E Biddle, Sarah E Smith-Jeffcoat, Melissa A Rolfes, Alexandra Mellis, H Keipp Talbot, Carlos Grijalva, Adam S Lauring   +15 more
doaj   +1 more source

Prediction and Realisation of Conversational Characteristics by Utilising Spontaneous Speech for Unit Selection [PDF]

, 2010
Unit selection speech synthesis has reached high levels of naturalness and intelligibility for neutral read aloud speech. However, synthetic speech generated using neutral read aloud data lacks all the attitude, intention and spontaneity associated with ...
Traum, David, Aylett, Matthew, Georgila, Kallirroi, Clark, Robert A. J., Andersson, Sebastian, Clark, Robert A J   +5 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source