Results 131 to 140 of about 12,935,991 (392)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Journal of Mathematical Analysis and Applications, 1974 Some examples and technical assumptions will appear in Section 2. We are looking in this paper for conditions on u and g which will imply that for every a there exists a measurable solution x(t) to the problem B(u, g, a). A somewhat weaker version of this problem, namely when X is the nonnegative orthant of the n-dimensional space and g(x, t) = x, was ...
openaire +2 more sources
Phenotypic variation in Calandrinia galapagosa (Portulacaceae) [PDF]
, 2003 Calandrinia galapagosa St. John is found only on San Cristóbal Island in the Galápagos archipelago, where it is severely threatened by feral goats.
Jaramillo, Patricia
core
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Evaluating environmental DNA detection of a rare fish in turbid water using field and experimental approaches [PDF]
PeerJDetection sensitivity of aquatic species using environmental DNA (eDNA) generally decreases in turbid water but is poorly characterized. In this study, eDNA detection targeted delta smelt (Hypomesus transpacificus), a critically endangered estuarine fish
Ann E. Holmes +5 more
doaj +2 more sources
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
Engineering Reports, 2019 India, a leading developing country in the Asian continent, is worldwide famous for its diversified and complex monsoon rainfall system, and the factors associated with it.
Shobha Shivaram Nandargi +1 more
doaj +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Adaptive individual variation in phenological responses to perceived predation levels
Nature Communications, 2019 For phenotypic plasticity to evolve to a changing world, there must be variation in plasticity. Here, the authors show that whether great tits advance or delay breeding in response to perceived predation risk depends on their personality, linking ...
Robin N. Abbey-Lee, Niels J. Dingemanse
doaj +1 more source