Results 161 to 170 of about 7,252,224 (344)

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Nature, 2009
S. Purcell, N. Wray, J. Stone, P. Visscher, M. O’Donovan, P. Sullivan, P. Sklar   +6 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Global variation in copy number in the human genome

Nature, 2006
R. Redon, S. Ishikawa, Karen R. Fitch, Lars Feuk, Lars Feuk, G. Perry, T. Andrews, H. Fiegler, M. Shapero, Andrew R. Carson, Andrew R. Carson, Wenwei Chen, Eun Kyung Cho, Stephanie Dallaire, J. Freeman, J. González, M. Gratacós, Jing Huang, Dimitrios Kalaitzopoulos, Daisuke Komura, J. MacDonald, C. Marshall, C. Marshall, R. Mei, Lyndal Montgomery, Keunihiro Nishimura, Kohji Okamura, Kohji Okamura, F. Shen, M. Somerville, J. Tchinda, A. Valsesia, Cara Woodwark, Fengtang Yang, Junjun Zhang, T. Zerjal, Jane Zhang, L. Armengol, D. Conrad, X. Estivill, X. Estivill, C. Tyler-Smith, N. Carter, H. Aburatani, Charles Lee, Charles Lee, K. W. Jones, Stephen W. Scherer, Stephen W. Scherer, M. Hurles   +49 more
semanticscholar   +1 more source

Evaluation and Interpretation of Genetic Effective Population Size of Delta Smelt from 2011–2014

San Francisco Estuary and Watershed Science, 2017
https://doi.org/10.15447/sfews.2017v15iss2art5Delta Smelt have collapsed demographically, but little is known about their current genetic status. We used 12 microsatellite loci to evaluate two measures of the effective population size (Ne) of Delta ...
Amanda J. Finger, Gregg Schumer, Alyssa Benjamin, Scott Blankenship   +3 more
doaj  

Discontinuous Variation [PDF]

Science, 1906
openaire   +2 more sources

Temporal variations of the carbon isotopic ratio of atmospheric methane observed at Ny Ålesund, Svalbard from 1996 to 2004 [PDF]

, 2006
Shinji Morimoto, Shuji Aoki, Takakiyo Nakazawa, Takashi Yamanouchi   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Investigating Variation in the Prevalence of Weathering in Faunal Assemblages in the UK: A Multivariate Statistical Approach [PDF]

, 2011
Richard Madgwick, Jacqui Mulville
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Variation in Variation Measurement: A Mapping Review of Methods to Study Clinical Variation. [PDF]

J Eval Clin Pract
Quinn AE, Black JE, Chew D, Williamson TS, Yergens D, Faris P, Au F, Fletcher JM, Sidhu S, Drummond R, Skidmore B, Manns B.   +11 more
europepmc   +1 more source