Results 21 to 30 of about 3,445,836 (224)
An Advection Scheme using Paired Explicit Runge-Kutta Time Integration for Atmospheric Modeling
Gaoyuan qixiangIn this paper， a new numerical scheme was proposed to solve the advection equation in a multi-moment nonhydrostatic dynamical core.To guarantee the shape-preserving property， the limiting operations are devised for a hybrid discretization framework ...
Zhaoyang SUN +3 more
doaj +1 more source
Towards a Balanced Regime of Intellectual Property Rights for Agricultural Innovations [PDF]
, 2023 The utilization of intellectual property (IP) rights in crop research is rapidly evolving, with an increasing number of countries and intergovernmental organizations becoming members of—and thereby ratifying the framework provided by—the International ...
Jefferson, David James; The Public Intellectual Property Resource for Agriculture (PIPRA) Department of Plant Sciences University of California, Davis +2 more
core +2 more sources
DStreaM: A Convective Term Approximation Approach That Corresponds to Pure Convection
MathematicsIn recent decades, considerable effort has been devoted to developing higher-order schemes for the discretization of convective terms that are both stable and reliable.
Kiril Shterev
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Variation diminishing Hankel operators
, 2020 This paper studies the variation diminishing property of linear time-invariant Hankel k-positive systems, i.e., systems whose Hankel operator maps inputs with k - 1 sign changes to outputs with at most the same variation.
Sepulchre, R, Grussler, C, ,
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Variation diminishing property of densities of uniform generalized order statistics
Generalized order statistics, Variation diminishing property, Meijer’s G-function,
Mariusz Bieniek
core +1 more source