Results 31 to 40 of about 14,240 (231)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Unimodality preservation in Markov chains [PDF]
, 1978 A subset of the stochastically monotone Markov chains has the property that the expectation of unimodal functions of the chain is itself unimodal in the initial state.
Keilson, Julian, Kester, Adri
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
An Advection Scheme using Paired Explicit Runge-Kutta Time Integration for Atmospheric Modeling
Gaoyuan qixiangIn this paper， a new numerical scheme was proposed to solve the advection equation in a multi-moment nonhydrostatic dynamical core.To guarantee the shape-preserving property， the limiting operations are devised for a hybrid discretization framework ...
Zhaoyang SUN +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
DStreaM: A Convective Term Approximation Approach That Corresponds to Pure Convection
MathematicsIn recent decades, considerable effort has been devoted to developing higher-order schemes for the discretization of convective terms that are both stable and reliable.
Kiril Shterev
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Convenient total variation diminishing conditions for nonlinear difference schemes [PDF]
, 1986 Convenient conditions for nonlinear difference schemes to be total-variation diminishing (TVD) are reviewed. It is shown that such schemes share the TVD property, provided their numerical fluxes meet a certain positivity condition at extrema values but ...
Tadmor, Eitan
core +1 more source
A typology of military conflict based on the Hirshleifer contest [PDF]
, 2021 In a canonical model of military conflict, victory and defeat depend stochastically on the difference of resources deployed by the conflict parties. The present paper offers a comprehensive analysis of that model.
Ewerhart, Christian +1 more
core +1 more source