Results 251 to 260 of about 4,772,239 (326)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

Uncovering hidden factors of cognitive resilience in Alzheimer's disease using a conditional-Gaussian mixture variational autoencoder. [PDF]

open access: yesNPJ Dement
Cao Y   +9 more
europepmc   +1 more source

DQN‐Guided Subset‐Induced OCSVM Kernel Approximation for Imbalanced Anomaly Detection

open access: yesIEEJ Transactions on Electrical and Electronic Engineering, EarlyView.
Anomaly detection under limited normal data remains a fundamental challenge due to severe class imbalance and scarcity of anomalies. We propose a novel framework that reformulates support vector selection in One‐Class SVM as a sequential decision‐making problem.
Wenqian Yu, Jiaying Wu, Jinglu Hu
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

open access: yesVIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf   +5 more
wiley   +1 more source

Combining kernelised autoencoding and centroid prediction for dynamic multi‐objective optimisation

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
Abstract Evolutionary algorithms face significant challenges when dealing with dynamic multi‐objective optimisation because Pareto optimal solutions and/or Pareto optimal fronts change. The authors propose a unified paradigm, which combines the kernelised autoncoding evolutionary search and the centroid‐based prediction (denoted by KAEP), for solving ...
Zhanglu Hou   +4 more
wiley   +1 more source

DrLS: Distortion‐Resistant Lossless Steganography via Colour Depth Interpolation

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT The lossless data steganography is to hide a certain amount of information into a container image. Previous lossless steganography methods fail to strike a balance between capacity, imperceptibility, accuracy, and robustness, commonly vulnerable to distortion on container images.
Youmin Xu   +3 more
wiley   +1 more source

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