Results 121 to 130 of about 18,872 (309)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Comparison of Three Theories for Vibration Analysis for Shell Models
CivilEngShells are significant structural components that are extensively utilized in numerous engineering fields, including architectural and infrastructural projects.
Maria Anna De Rosa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Lagrangian structures and multidimensional consistency [PDF]
, 2010 The conventional point of view is that the Lagrangian is a scalar object (or equivalently a volume form), which through the Euler-Lagrange equations provides us with one single equation (i.e., one per component of the dependent variable ...
Lobb, Sarah Beverley
core
Strong Convergence Theorem for a New General System of Variational Inequalities in Banach Spaces
Fixed Point Theory and Applications, 2010 We introduce a new system of general variational inequalities in Banach spaces. The equivalence between this system of variational inequalities and fixed point problems concerning the nonexpansive mapping is established.
Suantai S, Imnang S
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
An Extended Variational Formulation for Isothermal Gas Dynamic Lubrication [PDF]
, 2020 An extended variational formulation is derived which can be applied to problems in ...
D F Hays
core