Results 131 to 140 of about 18,872 (309)

Analysis of a rate-and-state friction problem with viscoelastic materials

Electronic Journal of Differential Equations, 2017
We consider a mathematical model which describes the frictional contact between a viscoelastic body and a foundation. The contact is modelled with normal compliance associated to a rate-and-state version of Coulomb's law of dry friction. We start by
Flavius Patrulescu, Mircea Sofonea
doaj  

Dyson–Schwinger Approach to Hamiltonian QCD

EPJ Web of Conferences, 2017
Dyson–Schwinger equations are an established, powerful non-perturbative tool for QCD. In the Hamiltonian formulation of a quantum field theory they can be used to perform variational calculations with non-Gaussian wave functionals.
Campagnari Davide, Reinhardt Hugo, Huber Markus Q., Vastag Peter, Ebadati Ehsan   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Note on a Variational Formulation of Electrodynamics [PDF]

, 2007
We present a variational formulation of electrodynamics using de Rham even and odd differential forms. By relying on a variational principle more complete than the Hamilton principle, our formulation leads to field equations with external sources and ...
DE NICOLA, Antonio, TULCZYJEW W. M.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A variational formulation for convection-diffusion problems [PDF]

, 1985
A variational principle is proposed that under certain restrictions is shown to be equivalent to the advection-diffusion boundary value problem. Based on this variational principle, an upwind finite element method is derived that precludes spurious ...
Ortiz, M.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Direct and indirect approximations to positive solution for a nonlinear reaction-diffusion problem. I. Direct (variational)

Journal of Numerical Analysis and Approximation Theory, 2002
We consider a nonlinear, second-order, two-point boundary value problem that models some reaction-diffusion precesses. When the reaction term has a particular form, \(f(u)=u^{3}\), the problem has a unique positive solution that satisfies a conserved ...
Călin-Ioan Gheorghiu, Damian Trif
doaj   +2 more sources

Variational Physics-Informed Neural Network for 3D Transient Melt Pool Thermal Modeling

Applied Sciences
Accurate prediction of transient melt pool thermal fields in Laser Powder Bed Fusion (LPBF) is essential for understanding melt pool geometry and defect formation mechanisms, yet conventional finite element methods (FEM) impose prohibitive computational ...
Zhenghao Xu, Xin Wang, Yuan Meng, Mingwei Wang, Xianglong Wang   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source