Results 71 to 80 of about 2,330,920 (308)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Fractional-Order Fidelity-Based Total Generalized Variation Model for Image Deblurring

Fractal and Fractional, 2023
Image deblurring is a fundamental image processing task, and research for efficient image deblurring methods is still a great challenge. Most of the currently existing methods are focused on TV-based models and regularization term construction; little ...
Juanjuan Gao, Jiebao Sun, Zhichang Guo, Wenjuan Yao   +3 more
doaj   +1 more source

Approximate Inference for Constructing Astronomical Catalogs from Images

, 2019
We present a new, fully generative model for constructing astronomical catalogs from optical telescope image sets. Each pixel intensity is treated as a random variable with parameters that depend on the latent properties of stars and galaxies.
Adams, Ryan P., McAuliffe, Jon D., Miller, Andrew C., Prabhat, Regier, Jeffrey, Schlegel, David   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Efficient Schemes for Total Variation Minimization Under Constraints in Image Processing [PDF]

SIAM Journal on Scientific Computing, 2009
This paper presents new fast algorithms to minimize total variation and more generally l1-norms under a general convex constraint. Such problems are standards of image processing. The algorithms are based on a recent advance in convex optimization proposed by Yurii Nesterov.
Weiss, Pierre, Blanc-Féraud, Laure, Aubert, Gilles   +2 more
openaire   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Bayesian 3-D interferometric ISAR imaging for the targets with limited pulses

The Journal of Engineering, 2019
It is difficult to yield high azimuth resolution of a target in short coherent processing interval, which brings certain challenges for the subsequent three-dimensional (3-D) interference inverse synthetic aperture radar (InISAR) imaging.
Xuefei Chen, Yong Wang
doaj   +1 more source

Approximate Analytical Methods for a Fractional-Order Nonlinear System of Jaulent–Miodek Equation with Energy-Dependent Schrödinger Potential

Fractal and Fractional, 2023
In this paper, we study the numerical solution of fractional Jaulent–Miodek equations with the help of two modified methods: coupled fractional variational iteration transformation technique and the Adomian decomposition transformation technique.
Saleh Alshammari, M. Mossa Al-Sawalha, Rasool Shah   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source