Results 101 to 110 of about 31,536,622 (369)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

THE METHOD OF SYSTEMATIC VARIATIONS

open access: yesSoil Science, 1963
info:eu-repo/semantics ...
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Variational iteration method with matrix Lagrange multiplier for nonlinear oscillators

open access: yesJournal of Low Frequency Noise, Vibration and Active Control, 2019
The variational iteration method is a famous mathematical tool to nonlinear oscillator, this paper shows that the method can be further improved by using matrix Lagrange multipliers.
Zhao-Ling Tao, Guo-Hua Chen, Yi-Han Chen
doaj   +1 more source

The Variate Difference Method

open access: yesSouthern Economic Journal, 1940
Commission's seal on t.-p. ; Bibliographical foot-notes. ; Mode of access: Internet.
Edgar Z. Palmer, Gerhard Tintner
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Ritz Variational Method for the Flexural Analysis of Rectangular Kirchhoff Plate on Winkler Foundation

open access: yesЖурнал інженерних наук, 2019
In this study, the Ritz variational method has been applied to solve the bending problem of rectangular Kirchhoff plate resting on Winkler foundation for the case of simply supported edges and transverse distributed load.
Ike C. C.
doaj   +1 more source

A Stein variational Newton method

open access: yes, 2018
Stein variational gradient descent (SVGD) was recently proposed as a general purpose nonparametric variational inference algorithm [Liu & Wang, NIPS 2016]: it minimizes the Kullback-Leibler divergence between the target distribution and its approximation
Cui, Tiangang   +4 more
core  

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

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