Results 71 to 80 of about 31,512,198 (344)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

A Novel Iterative Scheme and Its Application to Differential Equations

open access: yesThe Scientific World Journal, 2014
The purpose of this paper is to employ an alternative approach to reconstruct the standard variational iteration algorithm II proposed by He, including Lagrange multiplier, and to give a simpler formulation of Adomian decomposition and modified Adomian ...
Yasir Khan, F. Naeem, Zdeněk Šmarda
doaj   +1 more source

Variational model of scoliosis [PDF]

open access: yesTheoretical and Applied Mechanics, 2018
Scoliosis, being one of the most widespread spinal diseases among children, has been studied extensively throughout the history of medicine, yet there is no clear understanding of its initiating factors and the mechanogenesis of the monomorphic three ...
Popov Igor   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Modified Viscosity Subgradient Extragradient-Like Algorithms for Solving Monotone Variational Inequalities Problems

open access: yesAxioms, 2020
Variational inequality theory is an effective tool for engineering, economics, transport and mathematical optimization. Some of the approaches used to resolve variational inequalities usually involve iterative techniques.
Nopparat Wairojjana   +4 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Comparison between variational iteration method and Gegenbauer–Galerkin method for solving two dimensional nonlinear Volterra integral equations of the second kind [PDF]

open access: yesAIP Advances
This paper intends to introduce two numerical techniques—the variational iteration method and the Gegenbauer–Galerkin method—for obtaining solutions to two dimensional nonlinear Volterra integral equations of the second kind.
M. H. Ahmed
doaj   +1 more source

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