Results 61 to 70 of about 332,833 (326)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Hybrid Steepest-Descent Methods for Triple Hierarchical Variational Inequalities
Journal of Function Spaces, 2015 We introduce and analyze a relaxed iterative algorithm by combining Korpelevich’s extragradient method, hybrid steepest-descent method, and Mann’s iteration method.
L. C. Ceng +3 more
doaj +1 more source
Nonlinear Analysis, 2022 In this paper, we study the multiple solutions for some second-order p-Laplace differential equations with three-point boundary conditions and instantaneous and noninstantaneous impulses.
Yongfang Wei +2 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Numerical Solution of the Inverse Problem of Determining an Unknown Source Term in a Heat Equation
Journal of Applied Mathematics, 2012 This paper investigates the inverse problem of determining a heat source in the parabolic heat equation using the usual conditions. Firstly, the problem is reduced to an equivalent problem which is easy to handle using variational iteration method ...
Xiuming Li, Suping Qian
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An Optimal Control Problem Governed by a Kirchhoff-Type Variational Inequality
Journal of Applied Mathematics, 2020 This paper is concerned with an optimal control problem governed by a Kirchhoff-type variational inequality. The existence of multiplicity solutions for the Kirchhoff-type variational inequality is established by using some nonlinear analysis techniques ...
Chengfu Wang, Pengcheng Wu, Yuying Zhou
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A variational approach to the shock structure problem [PDF]
Theoretical and Applied Mechanics, 2005 A variational approach to the shock structure problem is proposed. The set of governing equations, consisted of n first-order ordinary differential equations accompanied with 2n boundary conditions at ±∞, is put into variational form by means of least ...
Simić Srboljub S.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
On the Variational Problems without Having Desired Variational Symmetries
Journal of Mathematics, 2013 We will have an attempt to present a method for constructing variational problems without having a desired one-parameter transformation group as a variational symmetry.
Mehdi Nadjafikhah +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source