Results 41 to 50 of about 1,168,562 (287)

Variational Time Integrators in Computational Solid Mechanics [PDF]

open access: yes, 2003
This thesis develops the theory and implementation of variational integrators for computational solid mechanics problems, and to some extent, for fluid mechanics problems as well.
Lew, Adrián José
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Variational principles for integrals [PDF]

open access: yesJournal of Computational Physics, 1969
We consider the problem of approximating integrals of the form ∫ 1W where W may be a simple (e.g. polynomial) form in the integration variables. A variational expression is given which approximates this integral in terms of integrals of W with suitably chosen trial functions.
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Variational Methods in Surface Parameterization [PDF]

open access: yes, 2005
A surface parameterization is a function that maps coordinates in a 2-dimensional parameter space to points on a surface. This thesis investigates two kinds of parameterizations for surfaces that are disc-like in shape.
Litke, Nathan Jacob
core   +1 more source

Infinitely many solutions for systems of n fourth order partial differential equations coupled with Navier boundary conditions

open access: yesArab Journal of Mathematical Sciences, 2014
In this paper, the existence of infinitely many solutions for a class of systems of n fourth order partial differential equations coupled with Navier boundary conditions is established.
Shapour Heidarkhani
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Hamilton-Pontryagin Integrators on Lie Groups [PDF]

open access: yes, 2007
In this thesis structure-preserving time integrators for mechanical systems whose configuration space is a Lie group are derived from a Hamilton-Pontryagin (HP) variational principle.
Bou-Rabee, Nawaf Mohammed
core   +1 more source

On Ekeland’s variational principle [PDF]

open access: yesJournal of Fixed Point Theory and Applications, 2011
For proper lower semi-continuous functionals bounded below which do not increase upon polarization, an improved version of Ekeland's variational principle can be formulated in Banach spaces, which provides almost symmetric points.
openaire   +4 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

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