Results 61 to 70 of about 1,168,562 (287)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Demonstratio MathematicaIn this paper, we establish a new version of Ekeland’s variational principle in the setting of Kaleva-Seikkala’s type fuzzy metric spaces, where the objective function is an interval-valued function defined on a fuzzy metric space, and the perturbation ...
Liu Xuan, He Fei, Lu Ning
doaj +1 more source
Abstract and Applied Analysis, 2014 This paper is devoted to the stochastic optimal control problems for systems governed by forward-backward stochastic Volterra integral equations (FBSVIEs, for short) with state constraints.
Qingmeng Wei, Xinling Xiao
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Auxiliary Principle for Generalized Strongly Nonlinear Mixed Variational-Like Inequalities
Journal of Inequalities and Applications, 2009 We introduce and study a class of generalized strongly nonlinear mixed variational-like inequalities, which includes several classes of variational inequalities and variational-like inequalities as special cases.
Zeqing Liu +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Some Aspects of Extended General Variational Inequalities
Abstract and Applied Analysis, 2012 Noor (“Extended general variational inequalities,” 2009, “Auxiliary principle technique for extended general variational inequalities,” 2008, “Sensitivity analysis of extended general variational inequalities,” 2009, “Projection iterative methods for ...
Muhammad Aslam Noor
doaj +1 more source
Variational Integrators in Holonomic Mechanics
Mathematics, 2020 Variational integrators for dynamic systems with holonomic constraints are proposed based on Hamilton’s principle. The variational principle is discretized by approximating the generalized coordinates and Lagrange multipliers by Lagrange polynomials, by ...
Shumin Man, Qiang Gao, Wanxie Zhong
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Iterative Schemes for a Class of Mixed Trifunction Variational Inequalities
Journal of Applied Mathematics, 2012 We use the auxiliary principle technique to suggest and analyze some iterative methods for solving a new class of variational inequalities, which is called the mixed trifunction variational inequality.
Muhammad Aslam Noor +2 more
doaj +1 more source