Results 51 to 60 of about 165,487 (274)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Comments on Joint Terms in Gravitational Action

, 2017
This paper compares three different methods about computing joint terms in on-shell action of gravity, which are identifying the joint term by the variational principle in Dirichlet boundary condition, treating the joint term as the limit contribution of
Ruan, Shan-Ming, Yang, Run-Qiu
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A generalized variational principle in b-metric spaces

Le Matematiche, 2014
In this paper we establish and prove a generalized variational principle for b-metric spaces. As a consequence, we obtain a weak Zhong-type variational principle in b-metric spaces.
Csaba Farkas, Andrea Éva Molnár, Szilard Nagy   +2 more
doaj  

Derivation of Two-Fluid Model Based on Onsager Principle

Entropy, 2022
Using the Onsager variational principle, we study the dynamic coupling between the stress and the composition in a polymer solution. In the original derivation of the two-fluid model of Doi and Onuki the polymer stress was introduced a priori; therefore,
Jiajia Zhou, Masao Doi
doaj   +1 more source

Self-energy-functional theory

, 2011
Self-energy-functional theory is a formal framework which allows to derive non-perturbative and thermodynamically consistent approximations for lattice models of strongly correlated electrons from a general dynamical variational principle.
Avella, Adolfo, Mancini, Ferdinando
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Ekeland’s variational principle for interval-valued functions with an α-level set in Kaleva-Seikkala’s type fuzzy metric spaces

Demonstratio Mathematica
In this paper, we establish a new version of Ekeland’s variational principle in the setting of Kaleva-Seikkala’s type fuzzy metric spaces, where the objective function is an interval-valued function defined on a fuzzy metric space, and the perturbation ...
Liu Xuan, He Fei, Lu Ning
doaj   +1 more source

The variational principle and effective action for a spherical dust shell

, 2003
The variational principle for a spherical configuration consisting of a thin spherical dust shell in gravitational field is constructed. The principle is consistent with the boundary-value problem of the corresponding Euler-Lagrange equations, and leads ...
Gladush, Valentin
core   +1 more source