Results 51 to 60 of about 21,521 (260)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Demonstratio MathematicaIn this paper, we establish a new version of Ekeland’s variational principle in the setting of Kaleva-Seikkala’s type fuzzy metric spaces, where the objective function is an interval-valued function defined on a fuzzy metric space, and the perturbation ...
Liu Xuan, He Fei, Lu Ning
doaj +1 more source
Abstract and Applied Analysis, 2014 This paper is devoted to the stochastic optimal control problems for systems governed by forward-backward stochastic Volterra integral equations (FBSVIEs, for short) with state constraints.
Qingmeng Wei, Xinling Xiao
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Auxiliary Principle for Generalized Strongly Nonlinear Mixed Variational-Like Inequalities
Journal of Inequalities and Applications, 2009 We introduce and study a class of generalized strongly nonlinear mixed variational-like inequalities, which includes several classes of variational inequalities and variational-like inequalities as special cases.
Zeqing Liu +3 more
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Some Aspects of Extended General Variational Inequalities
Abstract and Applied Analysis, 2012 Noor (“Extended general variational inequalities,” 2009, “Auxiliary principle technique for extended general variational inequalities,” 2008, “Sensitivity analysis of extended general variational inequalities,” 2009, “Projection iterative methods for ...
Muhammad Aslam Noor
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Variational Integrators in Holonomic Mechanics
Mathematics, 2020 Variational integrators for dynamic systems with holonomic constraints are proposed based on Hamilton’s principle. The variational principle is discretized by approximating the generalized coordinates and Lagrange multipliers by Lagrange polynomials, by ...
Shumin Man, Qiang Gao, Wanxie Zhong
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Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source