Results 51 to 60 of about 1,216,806 (296)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A generalized variational principle in b-metric spaces
Le Matematiche, 2014 In this paper we establish and prove a generalized variational principle for b-metric spaces. As a consequence, we obtain a weak Zhong-type variational principle in b-metric spaces.
Csaba Farkas +2 more
doaj
Moroccan Journal of Pure and Applied Analysis, 2017 In this paper, we prove the existence of in finitely many solutions for the following system by applying a critical point variational principle obtained by Ricceri as a consequence of a more general variational principle and the theory of the ...
Ahmed A. +2 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Demonstratio MathematicaIn this paper, we establish a new version of Ekeland’s variational principle in the setting of Kaleva-Seikkala’s type fuzzy metric spaces, where the objective function is an interval-valued function defined on a fuzzy metric space, and the perturbation ...
Liu Xuan, He Fei, Lu Ning
doaj +1 more source
Abstract and Applied Analysis, 2014 This paper is devoted to the stochastic optimal control problems for systems governed by forward-backward stochastic Volterra integral equations (FBSVIEs, for short) with state constraints.
Qingmeng Wei, Xinling Xiao
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Variational Principle for Ground Spaces [PDF]
Reports on Mathematical Physics, 2018 The ground spaces of a vector space of hermitian matrices, partially ordered by inclusion, form a lattice constructible from top to bottom in terms of intersections of maximal ground spaces. In this paper we characterize the lattice elements and the maximal lattice elements within the set of all subspaces using constraints on operator cones.
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source