Results 71 to 80 of about 1,168,562 (287)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Critical Point Theorems for Nonlinear Dynamical Systems and Their Applications
Fixed Point Theory and Applications, 2010 We present some new critical point theorems for nonlinear dynamical systems which are generalizations of Dancš-Hegedüs-Medvegyev's principle in uniform spaces and metric spaces by applying an abstract maximal element principle established ...
Wei-Shih Du
doaj +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
A parametrized variational principle of nonlinear piezoelectricity
Computer Assisted Methods in Engineering and Science, 2023 The variational theory is the theoretical basis of the finite element method, meshfree particle methods and other modern numerical techniques. The present paper establishes a family of variational principles for nonlinear piezoelectricity.
Ji-Huan He
doaj
Aspects of the Schwinger Variational Principle Formulation
Trends in Computational and Applied Mathematics, 2000 The application of the Schwinger variational principle-SVP and, in particular, the second Born approximation to the evaluation of scattering amplitude and integral cross sections for eletron-atom impact is ...
J.L.S. Lino +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
A variational principle for boundary-value problems with non-linear boundary conditions
Electronic Journal of Differential Equations, 2015 In this article, we establish a variational principle for a class of boundary-value problems with a suitable non-linear boundary conditions. As an application of the variational principle, we study the existence of classical solutions for boundary ...
Dianwu Yang
doaj
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Variational Methods for Nonsmooth Mechanics [PDF]
, 2003 In this thesis we investigate nonsmooth classical and continuum mechanics and its discretizations by means of variational numerical and geometric methods.
Fetecau, Razvan Constantin
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source