Results 91 to 100 of about 6,588,469 (297)
Spatial Variations of Fundamental Constants
, 1999 We show that observational limits on the possible time variation of constants of Nature are significantly affected by allowing for both space and time variation.
C. O'Toole +3 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Meertens number and its variations
, 2016 In 1998, Bird introduced Meertens numbers as numbers that are invariant under a map similar to the Godel encoding. In base 10, the only known Meertens number is 81312000.
Wu, Chai Wah
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The Mathematical Intelligencer, 2005 This "Mathematical Entertainments" column from the Intelligencer is an exposition of current investigations, rooted in recent work of Jim Propp, into "quasirandom" analogues of random walk and random aggregation processes. Featured are the "Goldbugs" and the "Rotor-router".
openaire +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Agricultura Tropica et SubtropicaCowpea is an important legume, and its wild relatives could be reliable sources of favorable alleles for genetic diversity and improvement of important traits.
Olayiwola Richard Oluseyi +3 more
doaj +1 more source
Solar gravitational energy and luminosity variations
, 2007 Due to non-homogeneous mass distribution and non-uniform velocity rate inside the Sun, the solar outer shape is distorted in latitude. In this paper, we analyze the consequences of a temporal change in this figure on the luminosity.
Ajabshirizadeh, A. +4 more
core +3 more sources