Results 121 to 130 of about 6,556,977 (297)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Endodontic Treatment Of Upper First Premolar With 3 Canals- Case Report
Journal of Rawalpindi Medical CollegeA comprehensive understanding of the root structure is important for the successful outcome of endodontic procedures. Lack of knowledge of the anatomic variations in root canal morphology can contribute to the failure of root canal therapy.
Dania Khan +5 more
doaj +1 more source
Dilemmas and controversies in the interpretation of laboratory results [PDF]
Journal of Medical Biochemistry, 2008 Concentration of many substances in blood is a good indicator of the physiologic state of a patient. It is usual that results obtained represent the real concentration of tested substances in a patient, that is, represent his physiological state.
Popović Danica, Popović Mirko
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
CLIMATE CHARACTERISTICS ALONG THE BULGARIAN BLACK SEA COAST FROM 1970 TO 2009 [PDF]
Aerul şi Apa: Componente ale Mediului, 2013 For the regime of meteorological elements in Bulgaria influence have air masses coming from Atlantic Ocean, Mediterranean and Black Sea, and from mainland Europe.
VENETA IVANOVA TODOROVA
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Koers : Bulletin for Christian Scholarship, 2018 This article discerns the ingredients leadership ought to employ when it functions within the plurifactorial dimensions of the sociological, economic, political, cultural, religious and class diversity.
Jennifer SLATER
doaj
Generalized quasi-variational hemi-variational inequalities
Applied Mathematics Letters, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source