Results 241 to 250 of about 642,033 (312)

Pangenomic analyses in the cultivated grapevine confirm high genomic collinearity and extensive dispensable gene content likely involved in adaptation. [PDF]

G3 (Bethesda)
Pierre B, Bacilieri R, This D, Lacombe T, Segura V, This P, Mocoeur A, Villoutreix R, Sarah G.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Metabolomics-Guided Bioactivity Evaluation of Disease-Resistant Hybrid Grape Canes for Cosmetic Valorization. [PDF]

ACS Omega
Ferrier M, Abdallah C, Malinowska MA, Garros L, Unlubayir M, Gémin MP, Giglioli-Guivarc'h N, Hano C, Lanoue A.   +8 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Establishment of Tissue Culture and Genetic Transformation Systems Using Mature Embryos of Bread Wheat. [PDF]

Plants (Basel)
He Y, Wang Y, Shi J, Pang S, Li W, Wang C, Ren L, Xu Z, Wang D, Zheng J.   +9 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Comparative phytochemical profiling and bioactivity evaluation of three Indonesian pomegranate (Punica granatum) peel varieties: Antioxidant, antibacterial, and in vitro antiproliferative activities. [PDF]

PLoS One
Saputro TB, Fadilah AS, Solihah A, Nurhayati APD, Chutimanukul P, Rizqi HD.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source