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An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses.
Journal of Medicinal Chemistry, 2023The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in orthopoxvirus antivirals. Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae family, which also includes the variola virus, vaccinia virus, and cowpox ...
Jun Wang +5 more
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Variola virus archives: a new century, a new approach
The Lancet, 2014Peter B. Jahrling, Owale Tomori
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The Infectious Dose of Variola (Smallpox) Virus
Applied Biosafety, 2004Quantitative estimation of an individual's risk of infection due to airborne pathogens requires knowledge of the pathogen's infectious dose, in addition to estimates of the pathogen's airborne conc...
Rachael M. Jones +3 more
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Experimental studies on transformation of the variola virus into the vaccinia virus
Archiv f�r die gesamte Virusforschung, 1963Variola- and alastrim field strains obtained from recent epidemics in India and Africa were inoculated and submitted to passages through heterologous host system in an attempt to obtain transformation into vaccinia virus. We studied in a similar manner variola virus strains cultivated in the embryonated egg, the mouse, and in tissue culture cells ...
H. Mahnel +3 more
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TNF binding protein of variola virus acts as a TNF antagonist at epicutaneous application.
Current Pharmaceutical Biotechnology, 2015VARV-CrmB is a TNF binding protein of variola virus. VARV-CrmB protein was previously shown to be active as a TNF-antagonist in a number of in vivo and in vitro models.
I. Gileva +5 more
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Genus Orthopoxvirus: Variola virus
2007Variola major virus caused the human disease smallpox; interpretations of the historic record indicate that the initial introduction of disease in a naive population had profound effects on its demographics. Smallpox was declared eradicated by the World Health Organization (WHO) in 1980.
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Gene homology between orf virus and smallpox variola virus
Virus Genes, 1996About 47% identity was observed between the deduced amino acid sequences of a protein encoded by a gene of the parapoxvirus orf virus (OV) strain NZ2 and a 6 kDa protein of unknown function reported to be produced by an open reading frame expressed early after infection by the orthopoxvirus Western Reserve vaccinia virus (VAC); the open reading frame ...
Joseph J. Esposito +2 more
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Targeting F13 from monkeypox virus and variola virus by tecovirimat: molecular simulation analysis.
Journal of Infection, 2022Daoqun Li +3 more
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Screening Studies with Variola Virus
1958Abstract : An investigation was initiated to screen variola virus. The experimental data are concerned with methods of assaying the virus quantitatively, determining optimal conditions for culture growth, and the effect of various physical and chemical reagents on its viability.
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Cytopathogenicity and Propagation of Variola Virus in Tissue Culture
The Journal of Immunology, 1958Summary Variola virus has been shown to induce cytologic changes and to propagate in a variety of human and animal cell strains derived from both normal and malignant tissue. One exception occurred in which the L cell strain was agglutinated by large virus quantities.
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