Results 111 to 120 of about 205,060 (282)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

PRICE, YIELD, AND GROSS REVENUE VARIABILITY FOR SELECTED GEORGIA CROPS

open access: yes
Demand and Price Analysis,
Lin, Kuang-Hsing T.   +1 more
core  

Contribution of High-Yield Varieties Seeds to Major Food Crops Production, Yield and Area in Punjab - Pakistan [PDF]

open access: yes
The present study is undertaken to measure the contribution of HYVs to major food crops (Wheat, rice, bajra, jowar and maize) production, yield and area in Pakistan Punjab. The study is based on secondary data for the last 44 years, i.e., from 1951-52 to
Mohammad Pervez Wasim
core  

Reasoned opinion on the modification of the existing MRLs for fluopyram in various crops

open access: yesEFSA Journal, 2014
In accordance with Article 6 of Regulation (EC) No 396/2005, Germany, hereafter referred to as the evaluating Member State (EMS), received an application from Bayer CropScience AG to modify the existing MRLs for the active substance fluopyram in various ...
European Food Safety Authority
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Producer income instability and farmers' risk response: The case of major Kenyan export crops [PDF]

open access: yes
The instability of export earnings in LDCs and its presumably harmful economic effects have been broadly discussed in the economic literature and among policy makers in international meetings.
Junginger-Dittel, Klaus-Otto   +1 more
core  

Modification of the existing maximum residue levels for acetamiprid in various crops. [PDF]

open access: yesEFSA J, 2021
EFSA (European Food Safety Authority)   +21 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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