Results 111 to 120 of about 881,071 (281)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Integrated economic modeling of global and regional micronutrient security: [PDF]
In this paper, we examine the implications of alternative country-specific scenarios for biofortification on the reduction of micronutrient deficiency prevalence in under-fives.
Batka, Miroslav +4 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Modification of the existing maximum residue levels and setting import tolerances for flupyradifurone and difluoroacetic acid (DFA) in various crops. [PDF]
EFSA J, 2023 European Food Safety Authority (EFSA) +21 more
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Optimal selection of passes [PDF]
Preliminary numerical results obtained from the application of a linear feature selection technique to the determination of combinations of passes which best discriminate between a given set of crops in a given area of interest, are reported. The results
Guseman, L. F., Jr., Marion, B. P.
core +1 more source
Torrefaction behaviour of various biomass types: kinetics of solid mass loss and release of volatiles [PDF]
, 2011 Feedstock variability is a crucial issue for industrialization of biomass conversion processes. Indeed, this variability may imply large differences of chemical reaction rates and products yields and therefore differences of reactors design.
Commandre, Jean-Michel +6 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Indian Seed System Development: Policy and Institutional Options [PDF]
Developments in the Indian seed industry and their impact on access and use of commercial seed by farmers have been examined. Various types of seed systems such as hybrids, self-pollinated crops, vegetatively propagated crops, crops with high seed volume,
Mathur, Prasoon +2 more
core +1 more source