Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Fusarium and mycotoxin spectra in Swiss barley are affected by various cropping techniques [PDF]
Torsten Schöneberg +8 more
openalex +1 more source
Is Futures Market Mitigating Price Risk: An Exploration of Wheat and Maize Market [PDF]
Instability of commodity prices has always been a major concern of the producers as well as the consumers in an agriculture-dominated country like India.
Jain, Praveen Kumar +3 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Is species diversity of various crop "pest taxa" proportionate to efforts paid to their research? A scientometric analysis in the Czech Republic - short note [PDF]
Václav Stejskal, Alois Honěk
openalex +1 more source
Integrated economic modeling of global and regional micronutrient security: [PDF]
In this paper, we examine the implications of alternative country-specific scenarios for biofortification on the reduction of micronutrient deficiency prevalence in under-fives.
Batka, Miroslav +4 more
core
Site Description for the University of Nebraska's Sandhills Agricultural Laboratory [PDF]
The Sandhills Agricultural Laboratory is operated by the University of Nebraska. The laboratory is located in the south-central part of the Nebraska Sandhills near Tryon, Nebraska (41 deg. 37' N; 100 deg. 50' W).
Blad, B. L., Gardner, B. R.
core +1 more source
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Modification of the existing maximum residue levels and setting import tolerances for flupyradifurone and difluoroacetic acid (DFA) in various crops. [PDF]
European Food Safety Authority (EFSA) +21 more
europepmc +1 more source

