Results 311 to 320 of about 1,424,595 (340)

Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification

Journal of Pathology, 2022
Vascular calcification is an actively regulated process resembling bone formation and contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD).
Zirong Lan, An Chen, Li Li, Yuanzhi Ye, Qingchun Liang, Q-L Dong, Siyi Wang, M. Fu, Yining Li, Xiaoyu Liu, Zhenyu Zhu, Jing-Song Ou, Xiaozhong Qiu, Lihe Lu, Jianyun Yan   +14 more
semanticscholar   +1 more source

Adipokines in vascular calcification

Clinica Chimica Acta, 2021
Adipose tissue (AT), a critical endocrine gland, is capable of producing and secreting abundant adipokines. Adipokines act on distant or adjacent organ tissues via paracrine, autocrine, and endocrine mechanism, which play attractive roles in the regulation of glycolipid metabolism and inflammatory response. Increasing evidence shows that adipokines can
Shun-Lin Qu, Chi Zhang, Xuan Xiao, Liang Huang, Yi-Duo Shao, Yi-Zhang Liu, Jia-Xiang Sun, Zhe-Bin Cheng   +7 more
openaire   +3 more sources

Vascular calcification

Current Opinion in Nephrology and Hypertension, 1999
Vascular calcification is an active and modifiable process involved in many disease entities, including atherosclerosis, cardiac valve disease and calcific uremic arteriolopathy. It occurs with distinct characteristics at different sites in the vessel wall.
R C, Christian, L A, Fitzpatrick
openaire   +2 more sources

Vascular calcification

Current Opinion in Nephrology & Hypertension, 2013
This review presents new evidence related to molecular mechanisms involved in the process of cardiovascular calcification, as well as to discuss new biomarkers and novel therapeutic strategies related to vascular calcification in chronic kidney disease (CKD) patients.microRNAs have emerged as potential players in the genesis of osteo-chondrogenic ...
Ziad A, Massy, Tilman B, Drüeke
openaire   +2 more sources

Vascular calcification in dermatopathology

The American Journal of Dermatopathology, 1979
Calcification in cutaneous blood vessels is an uncommon finding in biopsies submitted for dermatopathological examination. Of 14 biopsy specimens showing the phenomenon that was studied by us, the greater number was from women who had a combination of severe diabetes, hypertension, and atherosclerosis.
Richard K. Winkelmann, Steven Kossard
openaire   +3 more sources

The role of matrix Gla protein (MGP) in vascular calcification.

Current Medicinal Chemistry, 2020
Matrix Gla protein (MGP) is a vitamin K-dependent protein, which is synthesized in bone and many further mesenchymal cells, which is also highly expressed by vascular smooth 1muscle cells (VSMCs) and chondrocytes. Numerous studies have confirmed that MGP
Geir Bjorklund, Erik Svanberg, Maryam Dadar, D. Card, S. Chirumbolo, D. Harrington, J. Aaseth   +6 more
semanticscholar   +1 more source

The biology of vascular calcification

2020
Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases.
Quaglino D., Boraldi F., Lofaro F. D.
openaire   +3 more sources

Imaging for Vascular Calcification

Seminars in Dialysis, 2017
AbstractChronic decline in renal function is accompanied by deterioration of bone structure and function and progressive calcification of the vascular system. Both disease states have been linked with increased morbidity and mortality in chronic kidney disease.
Paolo Raggi, W. Charles O'Neill
openaire   +3 more sources

Pathophysiology of Vascular Calcification

Current Osteoporosis Reports, 2015
Vascular calcification can lead to cardiovascular morbidity and mortality. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The pathogenesis of vascular calcification is complex and involves a transformation of vascular smooth muscle cells to an osteo/chondrocytic cell that ...
Neal X. Chen, Sharon M. Moe, Sharon M. Moe   +2 more
openaire   +2 more sources

Inflammation and Vascular Calcification

Blood Purification, 2005
Both vascular calcification and inflammation are common in patients with chronic kidney disease (CKD). In patients on dialysis, there is increased coronary artery and peripheral artery calcification compared to the general population. Both intimal (atherosclerotic) and medial calcification in CKD patients are associated with increased morbidity and ...
Neal X. Chen, Sharon M. Moe
openaire   +3 more sources