Results 311 to 320 of about 1,468,943 (359)

Uremic Vascular Calcification

Journal of Investigative Medicine, 2006
Recent evidence suggests that uremic vascular calcification is an active, cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) and the bone-specific transcription factor core-binding
Neal X, Chen, Sharon M, Moe
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Adipokines in vascular calcification

Clinica Chimica Acta, 2021
Adipose tissue (AT), a critical endocrine gland, is capable of producing and secreting abundant adipokines. Adipokines act on distant or adjacent organ tissues via paracrine, autocrine, and endocrine mechanism, which play attractive roles in the regulation of glycolipid metabolism and inflammatory response. Increasing evidence shows that adipokines can
Xuan, Xiao, Yi-Zhang, Liu, Zhe-Bin, Cheng, Jia-Xiang, Sun, Yi-Duo, Shao, Shun-Lin, Qu, Liang, Huang, Chi, Zhang   +7 more
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Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation

Circulation Research
BACKGROUND: Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals.
Wenqi Ma, K. Jia, Haomai Cheng, Hong Xu, Zhigang Li, Hang Zhang, Hongyang Xie, Hang Sun, Lei Yi, Zhiyong Chen, Shengzhong Duan, M. Sano, Keiichi Fukuda, Lin Lu, Fei Gao, Ruiyan Zhang, Xiaoxiang Yan   +16 more
semanticscholar   +1 more source

Vascular calcification

Current Opinion in Nephrology & Hypertension, 2005
Accumulating evidence suggests that the high cardiovascular mortality observed in patients with end-stage renal disease is due in part to the deleterious effects of vascular calcification that develops over time on dialysis. This review focuses on recent cell biological and animal studies that have shed light on the mechanisms and regulators of ...
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The role of matrix Gla protein (MGP) in vascular calcification.

Current Medicinal Chemistry, 2020
Matrix Gla protein (MGP) is a vitamin K-dependent protein, which is synthesized in bone and many further mesenchymal cells, which is also highly expressed by vascular smooth 1muscle cells (VSMCs) and chondrocytes. Numerous studies have confirmed that MGP
Geir Bjorklund, Erik Svanberg, Maryam Dadar, D. Card, S. Chirumbolo, D. Harrington, J. Aaseth   +6 more
semanticscholar   +1 more source

Imaging for Vascular Calcification

Seminars in Dialysis, 2017
AbstractChronic decline in renal function is accompanied by deterioration of bone structure and function and progressive calcification of the vascular system. Both disease states have been linked with increased morbidity and mortality in chronic kidney disease.
Paolo, Raggi, W Charles, O'Neill
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Pathophysiology of Vascular Calcification

Current Osteoporosis Reports, 2015
Vascular calcification can lead to cardiovascular morbidity and mortality. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The pathogenesis of vascular calcification is complex and involves a transformation of vascular smooth muscle cells to an osteo/chondrocytic cell that ...
Neal X, Chen, Sharon M, Moe
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Inflammation and Vascular Calcification

Blood Purification, 2005
Both vascular calcification and inflammation are common in patients with chronic kidney disease (CKD). In patients on dialysis, there is increased coronary artery and peripheral artery calcification compared to the general population. Both intimal (atherosclerotic) and medial calcification in CKD patients are associated with increased morbidity and ...
Sharon M, Moe, Neal X, Chen
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Vascular calcification in dermatopathology

The American Journal of Dermatopathology, 1979
Calcification in cutaneous blood vessels is an uncommon finding in biopsies submitted for dermatopathological examination. Of 14 biopsy specimens showing the phenomenon that was studied by us, the greater number was from women who had a combination of severe diabetes, hypertension, and atherosclerosis.
S, Kossard, R K, Winkelmann
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Preventing vascular calcification

Science, 2016
Vascular Disease The arterial calcification that develops in patients with the genetic disease ACDC (arterial calcification due to deficiency of CD73) leads to peripheral ischemia. Cells from these patients have increased levels of an enzyme that degrades pyrophosphate, a compound that inhibits calcification. Jin et al.
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