Results 321 to 330 of about 1,424,595 (340)
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Journal of Investigative Medicine, 2006
Recent evidence suggests that uremic vascular calcification is an active, cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) and the bone-specific transcription factor core-binding
Sharon M. Moe, Neal X. Chen
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Recent evidence suggests that uremic vascular calcification is an active, cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) and the bone-specific transcription factor core-binding
Sharon M. Moe, Neal X. Chen
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Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
Circulation ResearchBACKGROUND: Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals.
Wenqi Ma +16 more
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Current Opinion in Nephrology & Hypertension, 2005
Accumulating evidence suggests that the high cardiovascular mortality observed in patients with end-stage renal disease is due in part to the deleterious effects of vascular calcification that develops over time on dialysis. This review focuses on recent cell biological and animal studies that have shed light on the mechanisms and regulators of ...
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Accumulating evidence suggests that the high cardiovascular mortality observed in patients with end-stage renal disease is due in part to the deleterious effects of vascular calcification that develops over time on dialysis. This review focuses on recent cell biological and animal studies that have shed light on the mechanisms and regulators of ...
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Warfarin and Vascular Calcification
The American Journal of Medicine, 2016The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP).
Timothy J. Poterucha +1 more
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Cardiovascular Research, 2020
AIMS Uromodulin is produced exclusively in the kidney and secreted into both urine and blood. Serum levels of uromodulin are correlated with kidney function and reduced in chronic kidney disease (CKD) patients, but physiological functions of serum ...
I. Alesutan +21 more
semanticscholar +1 more source
AIMS Uromodulin is produced exclusively in the kidney and secreted into both urine and blood. Serum levels of uromodulin are correlated with kidney function and reduced in chronic kidney disease (CKD) patients, but physiological functions of serum ...
I. Alesutan +21 more
semanticscholar +1 more source
VASCULAR CALCIFICATION IN PATIENTS WITH KIDNEY DISEASE: The Vascular Biology of Calcification
Seminars in Dialysis, 2007AbstractVascular calcification is an active, cell‐mediated process that results from an imbalance between the promoters and inhibitors of mineralization. The process of vascular calcification shares many similarities with that of skeletal mineralization.
Rukshana Shroff, Catherine M. Shanahan
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Omics research in vascular calcification
Clinica Chimica Acta, 2020Vascular calcification (VC), the pathological process of hydroxyapatite mineral deposition in the vascular system, is closely associated with aging, atherosclerotic plaque formation, cardiovascular disease (CVD) and diabetes mellitus (DM). Studies have shown that VC is related to cellular phenotypic changes, extracellular vesicles, disordered calcium ...
Meng Duan +5 more
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2002
Vascular calcification is a pathological calcification process. Its pathogenesis involves active mineralization by chondrogenic and osteogenic cells. Since cartilaginous metaplasia has been found in several vascular diseases, this process may represent one of vascular remodeling in response to vascular injury.
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Vascular calcification is a pathological calcification process. Its pathogenesis involves active mineralization by chondrogenic and osteogenic cells. Since cartilaginous metaplasia has been found in several vascular diseases, this process may represent one of vascular remodeling in response to vascular injury.
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Vascular calcification and bone disease: the calcification paradox
Trends in Molecular Medicine, 2009Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated process, increasingly recognized as a general cardiovascular risk factor. Remarkably, ectopic artery mineralization is frequently accompanied by decreased bone mineral density or disturbed bone turnover.
Persy, Veerle, d' Haese, Patrick C.
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Preventing vascular calcification
Science, 2016Vascular Disease The arterial calcification that develops in patients with the genetic disease ACDC (arterial calcification due to deficiency of CD73) leads to peripheral ischemia. Cells from these patients have increased levels of an enzyme that degrades pyrophosphate, a compound that inhibits calcification. Jin et al.
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