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GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
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Circulating selectins, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in hyperthyroidism.

The Journal of Clinical Endocrinology & Metabolism, 1995
Serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), soluble P-selectin, and soluble L-selectin (sL-selectin), tumor necrosis factor-alpha, and interleukin-6 were measured in patients with Graves' disease (GD) (n = 33), in patients with toxic ...
C, Wenisch, D, Myskiw, A, Gessl, W, Graninger   +3 more
openaire   +3 more sources

Expression of intercellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 in human crescentic glomerulonephritis

Histopathology, 2002
Expression of intercellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 in human crescentic glomerulonephritisAims:  In glomerulonephritis, intercellular adhesion molecule‐1 (ICAM‐1) and vascular cell adhesion molecule‐1 (VCAM‐1) may play important roles in the formation of crescents.
K C, Moon, S Y, Park, H W, Kim, H K, Hong, H S, Lee   +4 more
openaire   +2 more sources

Soluble Intercellular Adhesion Molecule 1 and Soluble Vascular Cell Adhesion Molecule 1 in Sudden Hearing Loss

Otology & Neurotology, 2008
The aim of the present study was to evaluate the concentration of soluble intercellular adhesion molecule 1 and soluble vascular cell adhesion molecule 1 in patients affected by sudden sensorineural hearing loss (SSHL).Prospective study.Tertiary referral center.Patients affected by SSHL were evaluated.
QUARANTA, Nicola Antonio Adolfo, RIA, ROBERTO, RAMUNNI A., BRESCIA P., DELIA A., VACCA, Angelo   +5 more
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Alterations in soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in hemodialysis patients

American Journal of Kidney Diseases, 1996
Hemodialysis (HD) patients can develop acute reactions during treatment as well as increased long-term susceptibility to infections and malignancies. Abnormalities in leukocyte adhesion may contribute to these processes. Recently, serum levels of soluble adhesion molecules have been detected in circulating blood of normal subjects and in patients with ...
H, Rabb, E, Calderon, P A, Bittle, G, Ramirez   +3 more
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Inhibitors of vascular cell adhesion molecule-1 expression

Expert Opinion on Therapeutic Patents, 2003
Leukocyte extravasation, a complex multistep process involving the selective recruitment of white blood cell subpopulations to specific tissues, is finely regulated to a large extent by inducible adhesion molecules on the endothelium. Secreted mediators such as tumour necrosis factor alpha (TNF-α) transcriptionally activate endothelial cells at sites ...
Erwin P Schreiner, Berndt Oberhauser, Carolyn A Foster   +2 more
openaire   +1 more source

Expression of Vascular Cell Adhesion Molecule-1 by Follicular Dendritic Cells

Leukemia & Lymphoma, 1995
Follicular dendritic cells are the major supporting cell of the germinal center microenvironment. The major function of follicular dendritic cells is to present antigen to B cells in secondary lymphoid tissues. Through cell-cell interactions, FDCs are hypothesized to be central to the regulation of normal B cell growth and differentiation.
M J, Huang, L, Osborn, J, Svahn, S B, Schiffer, L, Eliseo, L J, Zhou, K, Rhynhart, C D, Benjamin, A S, Freedman   +8 more
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Gold sodium thiomalate down-regulates intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on vascular endothelial cells.

Molecular Pharmacology, 1994
We examined whether antirheumatic drugs alter cytokine- or lipopolysaccharide-induced expression of adhesion molecules on vascular endothelial cells. Human umbilical cord vein endothelial cells were co-cultured with various antirheumatic drugs in the presence of inflammatory cytokines, and adhesion molecule expression was measured by cell enzyme-linked
R, Koike, I, Miki, M, Otoshi, T, Totsuka, H, Inoue, H, Kase, I, Saito, N, Miyasaka   +7 more
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Soluble Vascular Cell Adhesion Molecule-1 in Perennial Allergic Rhinitis

Acta Oto-Laryngologica, 1998
Since the expression of vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells plays a central part in the selective recruitment of eosinophils into allergic inflammatory lesions, VCAM-1 may be a key molecule in allergic inflammatory diseases.
Y, Ohashi, Y, Nakai, A, Tanaka, Y, Kakinoki, Y, Ohno, Y, Washio, T, Masamoto, A, Kato, H, Sakamoto   +8 more
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Cloning of murine and rat vascular cell adhesion molecule-1

Biochemical and Biophysical Research Communications, 1992
Vascular cell adhesion molecule-1 (VCAM1) is a member of the immunoglobulin (Ig) superfamily which interacts with the integrin very late antigen 4 (VLA4). We have cloned the cDNAs for both murine and rat VCAM1 from endotoxin-treated lung libraries.
C, Hession, P, Moy, R, Tizard, P, Chisholm, C, Williams, M, Wysk, L, Burkly, K, Miyake, P, Kincade, R, Lobb   +9 more
openaire   +2 more sources