Results 121 to 130 of about 4,094,904 (310)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3

Journal of Lipid Research
Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis.
Si Chen, Jian-Jun Gao, Yu-Jia Liu, Zhi-Wei Mo, Fang-Yuan Wu, Zuo-Jun Hu, Yue-Ming Peng, Xiao-Qin Zhang, Zhen-Sheng Ma, Ze-Long Liu, Jian-Yun Yan, Zhi-Jun Ou, Yan Li, Jing-Song Ou   +13 more
doaj   +1 more source

Functions and application of circRNAs in vascular aging and aging-related vascular diseases

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding RNAs generated through the reverse splicing of mRNA precursors, possess the capacity to regulate gene transcription and translation.
Cong Li, Sha-Qi He, Bei Huang, Jun-Jie Yang, Feng-Rong Liu, Ling-Qing Yuan, Xiao Lin, Jun Liu, Feng Xu   +8 more
core   +1 more source

Impact of vascular diseases on the progression of mild cognitive impairment to Alzheimer’s disease

, 2015
Introduction: Mild cognitive impairment does not meet the criteria for the diagnosis of dementia, but reaching this diagnosis raises concern about the future state of a patient due to the possibility of the conversion to Alzheimer’s disease.
Maria Barcikowska, Tomasz Nesteruk, Maria Styczyńska, Marta Nesteruk   +3 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Research on cross-dataset cardiac signal domain generalization and feature interpretability

Scientific Reports
Cross-dataset modeling of electrocardiogram signals faces the dual challenges of domain shift and insufficient interpretability in clinical applications. To address these issues, this study proposes a Transformer-based cross-domain ECG modeling framework
Runwen Li, Yierpani Aierken, Yu Xu, Jiang Liu, Yongjiang Tang   +4 more
doaj   +1 more source

Retinal vascular diseases reflecting generalized vascular alterations. What can be mutually learnt?

, 2014
Retinal vascular diseases are mostly caused by systemic vascular diseases. In some cases the systemic disease is already known but in other patients ocular anomalies often provide the first indications of a systemic disease.
Feltgen, Nicolas, Zeitz, P. Franko
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Endovascular bailout for closure-device failure following percutaneous endovascular aneurysm repair: A selective approach

Journal of Vascular Surgery Cases and Innovative Techniques
Objective: Suture-mediated closure devices have enabled totally percutaneous endovascular aneurysm repair (EVAR). Although hemorrhagic access-site complications are well recognized, closure-device related common femoral artery (CFA) stenosis or ...
Nivedita Mitta, MD, Umar Sadat, MD, PhD, FRCS, FRCP, FACS, FHEA, Angelos Karelis, MD, PhD, Márton Berczeli, MD, PhD, Björn Sonesson, MD, PhD, Nuno V. Dias, MD, PhD   +5 more
doaj   +1 more source