Results 111 to 120 of about 1,768,847 (310)

Endovascular single-branched stent graft to treat complicated type B aortic dissection involving aortic arch anomalies

European Journal of Medical Research
Background The optimal treatment of complicated type B aortic dissection (cTBAD) involving arch anomalies remain unclear. Methods We consecutively enrolled patients with cTBAD involving arch anomalies who underwent endovascular repair using a single ...
Mengyang Kang, Hao Qin, Yan Meng, Qiang Ma, Junbo Zhang, Hongyan Tian   +5 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Оптимизация учебной программы по физическому воспитанию студентов, имеющих отклонения со стороны здоровья. [PDF]

, 2018
The purpose of research - to identify ways to optimize the physical education curriculum for students with poor health, with diseases of the cardio-vascular system.To achieve the goal, we used the following methods: analysis of scientific and ...
Biletska, Viktoriia, Pryimakov, Alexandr, Pryimakova, Olga   +2 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Impact of inferior vena cava thrombosis on the prevalence of pulmonary embolism in patients with lower extremity deep vein thrombosis

Scientific Reports
Inferior vena cava thrombosis (IVCT) is a special form of venous thromboembolism. Lower extremity deep vein thrombosis (LEDVT) is associated with an increased incidence of pulmonary embolism (PE), but the association between concomitant IVCT and PE in ...
Yiman Zhang, Yan Meng, You Li, Mengyang Kang, Qiang Ma, Junbo Zhang, Jian Yang, Hongyan Tian, Qian Yin   +8 more
doaj   +1 more source

The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3

Journal of Lipid Research
Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis.
Si Chen, Jian-Jun Gao, Yu-Jia Liu, Zhi-Wei Mo, Fang-Yuan Wu, Zuo-Jun Hu, Yue-Ming Peng, Xiao-Qin Zhang, Zhen-Sheng Ma, Ze-Long Liu, Jian-Yun Yan, Zhi-Jun Ou, Yan Li, Jing-Song Ou   +13 more
doaj   +1 more source

Distinctive Mechanisms and Patterns of Exudative Versus Tractional Intraretinal Cystoid Spaces as Seen With Multimodal Imaging. [PDF]

, 2020
PurposeTo determine clear-cut distinctions between tractional and exudative intraretinal cystoid spaces subtypes.DesignRetrospective, multicenter, observational case series.MethodsA cohort of patients diagnosed with intraretinal cystoid spaces and imaged
Au, Adrian, Chehaibou, Ismael, Couturier, Aude, Govetto, Andrea, Grondin, Christelle, Hubschman, Jean-Pierre, Romano, Mario R, Sarraf, David, Tadayoni, Ramin, Virgili, Gianni   +9 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Evaluation of extended direct oral anticoagulant dosing strategies in patients with and without cancer from a prospective observational registry

Research and Practice in Thrombosis and Haemostasis
Background: Low-dose direct oral anticoagulants (DOACs) have been studied in randomized controlled trials for extended prevention of venous thromboembolism (VTE) after 6 months at therapeutic doses.
Danielle T. Vlazny, Robert D. McBane, Ana I. Casanegra, David O. Hodge, Teresa Lang, Waldemar E. Wysokinski, Lisa Peterson, Damon E. Houghton   +7 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source