Results 111 to 120 of about 3,949,064 (313)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Predicting adverse events after thoracic endovascular aortic repair for patients with type B aortic dissection

Scientific Reports
The potential of adverse events (AEs) after thoracic endovascular aortic repair (TEVAR) in patients with type B aortic dissection (TBAD) has been reported.
Mengyang Kang, You Li, Yiman Zhang, Yang Zhao, Yan Meng, Junbo Zhang, Hongyan Tian   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

BMP signaling in vascular diseases [PDF]

, 2012
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors.
Cai, J., Sánchez-Duffhues, Gonzalo, Cai, Jie, Peter ten Dijke, Gonzalo Sánchez-Duffhues, Pardali, E., Pardali, Evangelia, Jie Cai, Dijke, P. ten, Evangelia Pardali, Sanchez-Duffhues, G., ten Dijke, Peter   +11 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

DIAGNOSTIC ASPECTS OF SYSTEMIC INFLAMMATORY RESPONSE IN EARLY NEONATAL SEPSIS

Вестник анестезиологии и реаниматологии, 2017
Currently the neonatal sepsis is a major cause of mortality in the neonatal resuscitation and intensive care units. Systemic inflammatory response (SIR) is considered as the main pathogenetic component of sepsis.
O. G. Kryuchkova, E. A. Velikanova, E. V. Grigor'ev   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Endovascular single-branched stent graft to treat complicated type B aortic dissection involving aortic arch anomalies

European Journal of Medical Research
Background The optimal treatment of complicated type B aortic dissection (cTBAD) involving arch anomalies remain unclear. Methods We consecutively enrolled patients with cTBAD involving arch anomalies who underwent endovascular repair using a single ...
Mengyang Kang, Hao Qin, Yan Meng, Qiang Ma, Junbo Zhang, Hongyan Tian   +5 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice

, 2012
Aims: to determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.Methods: female C57BL6J mice were fed an obesogenic high fat diet (HF, 45%
Geraldine F Clough, Clough, G.F., Torrens Christopher, Mann, Giovanni E.; id_orcid, Hanson Mark A., Mann Giovanni E., Kimberley D Bruce, Cagampang Felino R. A., Christopher Torrens (114420), Mann, G.E., Ethirajan Priya, Richard C M Siow, Geraldine F. Clough (114433), Byrne Christopher D., Christopher D. Byrne (114429), Siow, Richard C. M.; id_orcid, Felino R. A. Cagampang (114423), Ethirajan, Priya, Cagampang, Felino R. A., Mark A. Hanson (114427), Bruce, K.D., Byrne, Christopher D., Richard C. M. Siow (114425), Giovanni E. Mann (114431), Priya Ethirajan, Mark A Hanson, Kimberley D. Bruce (114422), Bruce Kimberley D., Siow Richard C. M., Christopher D Byrne, Ethirajan, P., Priya Ethirajan (114421), Clough Geraldine F., Torrens, Christopher, Felino R A Cagampang, Giovanni E Mann, Hanson, Mark A., Christopher Torrens, Bruce, Kimberley D., Clough, Geraldine F., Siow, R.C., Cagampang, F.R.   +41 more
core   +1 more source