Results 81 to 90 of about 3,949,064 (313)
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Outcome of primary PCI – An Indian tertiary care center experience
Indian Heart Journal, 2014 Objective: To assess the feasibility and outcomes of primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) in Indian Scenario.
Vijayakumar Subban +11 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Key role for VSMCs in vascular remodeling and calcification [PDF]
, 2020 This research shows that cardiovascular diseases, such as vascular calcification and thrombosis, should be addressed and treated differently. Instead of the regular treatment of symptoms (i.e.
Jaminon, Armand Mario Gerard
core +5 more sources
Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Embolotherapy in vascular disease [PDF]
American Journal of Roentgenology, 1984 Embolotherapy for nonneoplastic vascular diseases including hemorrhage and congenital vascular malformations is reviewed. Application of short, intermediate, and long-acting embolic materials to these conditions is presented along with potential complications associated with their misuse.
openaire +2 more sources
Management of vascular diseases
, 2014 This thesis is about management of vascular diseases divided into three parts including arterial,venous and lymphatic disorders mainly focusing on pharmacological treatments.általános orvosangolegységes ...
Ghalegolab Behbahani, Arman
core