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Vascular Endothelial Growth Factor and Angiogenesis
Pharmacological Reviews, 2004Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for
Ann, Hoeben +5 more
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Vascular Endothelial Growth Factor
Ceskoslovenska fysiologie, 2012VEGF, vascular endothelial growth factor, is a substance firstly described in 1983 as a tumor-secreted protein which causes the development of ascitic fluid in case of abdominal tumors. Its influence on angiogenesis was ascertained by many studies. The strongest stimulus for its production is hypoxia, which leads to higher secretion of VEGF and new ...
R, Kaiser, P, Dubový, P, Haninec
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Intravitreal vascular endothelial growth factor
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014To evaluate whether a specific pre-analytical stabilization regimen is needed for naïve vitreous taps to detect true values of intrinsic VEGF levels.Fourteen consecutive patients with different vitreomacular pathologies without blood-retina-barrier breakdown were scheduled for standard 23-gauge three-port pars plana vitrectomy, and naïve vitreous taps ...
Thomas, Bertelmann +6 more
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1999
Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the ...
P, Carmeliet, D, Collen
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Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the ...
P, Carmeliet, D, Collen
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Trends in Cardiovascular Medicine, 1998
The endothelial cells lining all vessels of the circulatory system have been recognized as key players in a variety of physiological and pathological settings. They act as regulators of vascular tone via the inducible nitric oxide system and in angiogenesis, the formation of blood vessels de novo. Aberrant regulation of endothelial cells contributes to
B, Enholm +3 more
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The endothelial cells lining all vessels of the circulatory system have been recognized as key players in a variety of physiological and pathological settings. They act as regulators of vascular tone via the inducible nitric oxide system and in angiogenesis, the formation of blood vessels de novo. Aberrant regulation of endothelial cells contributes to
B, Enholm +3 more
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Vascular endothelial growth factor
Ophthalmology, 2007Vascular endothelial growth factor (VEGF) signalling is a key stimulant of tumour neovascular growth, survival and capillary permeability, which are critical to solid tumour progression. The intracellular signalling responses that induce an angiogenic phenotype are dependent upon VEGF binding to specific transmembrane receptors on the endothelium and ...
Neil Swanson, Anthony Gershlick
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Vascular endothelial growth factor
The International Journal of Biochemistry & Cell Biology, 1998Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis in development, in cancer and in other important diseases. VEGF regulates multiple endothelial cell functions including mitogenesis, permeability, vascular tone, and the production of vasoactive molecules.
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Frontiers in Bioscience, 2007
Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo, Cai, Xiaoyuan, Chen
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Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo, Cai, Xiaoyuan, Chen
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Vascular Endothelial Growth Factor in Cervical Carcinoma
Obstetrics & Gynecology, 1999To quantitate vascular endothelial growth factor of cervical carcinoma and elucidate its clinical correlation.Intratumoral protein levels of vascular endothelial growth factor were measured in 104 cervical cancer patients and in 30 cervical tissue specimens of benign gynecologic diseases as controls. The concentrations were correlated with clinical and
W F, Cheng +5 more
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Vascular Endothelial Growth Factor and its Receptors
Retina, 1994Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells and an angiogenic factor that is structurally related to platelet derived growth factor (PDGF). It is also known as the vascular permeability factor (VPF) because it efficiently potentiates the permeabilization of blood vessels. Five types of VEGF mRNA
G, Neufeld +4 more
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