Results 271 to 280 of about 446,360 (313)

Prognostic Importance of Vascular Endothelial Growth Factor-A Expression and Vascular Endothelial Growth Factor Polymorphisms in Epithelial Ovarian Cancer

International Journal of Gynecological Cancer, 2009
Vascular endothelial growth factors (VEGFs) play a central role in angiogenesis and consequently, in various steps of ovarian carcinogenesis. Gene polymorphisms within the VEGF system have revealed a correlation with prognosis in some malignancies. The aim of the present study was to examine the possible importance of 2 VEGF polymorphisms and VEGF-A ...
Smerdel, Maja, Waldstrøm, Marianne, Brandslund, Ivan, Steffensen, Karina Dahl, Andersen, Rikke Fredslund, Jakobsen, Anders   +5 more
openaire   +3 more sources

Lidocaine inhibits vascular endothelial growth factor-A-induced angiogenesis

Journal of Anesthesia, 2020
Angiogenesis is closely related to the pathophysiology of diseases such as cancer or ischemia. Here, we investigated the effect of lidocaine at clinically effective blood concentrations on vascular endothelial growth factor A (VEGF-A)-induced angiogenesis.
Shogo Suzuki, Atsushi Mori, Aya Fukui, Yoshiaki Ema, Kimitoshi Nishiwaki   +4 more
openaire   +2 more sources

Vascular Endothelial Growth Factor (VEGF) Inhibition - A Critical Review

Anti-Cancer Agents in Medicinal Chemistry, 2007
Angiogenesis, or formation of new blood capillaries from preexisting vessels, plays both beneficial and damaging roles in the organism. It is a result of a complex balance of positive and negative regulators, and vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic factors involved in tumor angiogenesis.
Irina Sousa, Moreira, Pedro Alexandrino, Fernandes, Maria João, Ramos   +2 more
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Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

Science, 1989
Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. Complementary DNA clones for bovine and human VEGF were isolated from cDNA libraries prepared from FC
D W, Leung, G, Cachianes, W J, Kuang, D V, Goeddel, N, Ferrara   +4 more
openaire   +2 more sources

Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine

1997
VPF/VEGF is a multifunctional cytokine that contributes to angiogenesis by both direct and indirect mechanisms. On the one hand, VPF/VEGF stimulates the endothelial cells lining nearby microvessels to proliferate, to migrate and to alter their pattern of gene expression.
L F, Brown, M, Detmar, K, Claffey, J A, Nagy, D, Feng, A M, Dvorak, H F, Dvorak   +6 more
openaire   +2 more sources

Vascular Endothelial Growth Factor in Central Nervous System Injuries – A Vascular Growth Factor Getting Nervous?

Current Neurovascular Research, 2008
Vascular Endothelial Growth Factor (VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in various central nervous system (CNS) disorders.
Mattias K, Sköld, Martin, Kanje
openaire   +2 more sources

Vascular endothelial growth factor, a specific regulator of angiogenesis

Current Opinion in Nephrology and Hypertension, 1996
Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells.
N, Ferrara, S, Bunting
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Vascular Endothelial Growth Factor (VEGF) in Astrocytic Gliomas – A Prognostic Factor?

Journal of Neuro-Oncology, 1999
Survival in astrocytic gliomas is closely related to WHO tumor grade. Within one tumor grade, especially in grade II and III tumors, the clinical course is variable and can hardly be predicted by histological criteria. Neovascularization is a neuropathological hallmark in high grade gliomas and angiogenic factors may play an important role in malignant
R D, Oehring, M, Miletic, M M, Valter, T, Pietsch, J, Neumann, R, Fimmers, U, Schlegel   +6 more
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Vascular endothelial growth factor in CSF

Neurology, 2000
To determine the value of vascular endothelial growth factor (VEGF) in CSF as a marker for carcinomatous meningitis (CM).The concentration of VEGF was measured by ELISA in matched samples of CSF and serum collected from 162 patients. These included patients with solid tumors with CM (n = 11) or brain metastases without concomitant CM (n = 12 ...
G, Stockhammer, W, Poewe, S, Burgstaller, F, Deisenhammer, A, Muigg, S, Kiechl, E, Schmutzhard, H, Maier, S, Felber, P, Schumacher, E, Gunsilius, G, Gastl   +11 more
openaire   +2 more sources

Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses

Brain Research, 2004
In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells.
Nico, Beatrice, De Giorgis, Michela, Vacca, Angelo, Roncali, Luisa, Ribatti, Domenico, MANGIERI, DOMENICA, CORSI, PATRIZIA   +6 more
openaire   +3 more sources