Results 111 to 120 of about 650,658 (370)

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source

Pattern formation of vascular network in a mathematical model of angiogenesis [PDF]

arXiv, 2021
We discuss the characteristics of the patterns of the vascular networks in a mathematical model for angiogenesis. Based on recent in vitro experiments, this mathematical model assumes that the elongation and bifurcation of blood vessels during angiogenesis are determined by the density of endothelial cells at the tip of the vascular network, and ...
arxiv  

Fluid shear stress-induced transcriptional activation of the vascular endothelial growth factor receptor-2 gene requires Sp1-dependent DNA binding [PDF]

Hemodynamic forces play a fundamental role in the regulation of endothelial cell survival. As signaling via the vascular endothelial growth factor (VEGF) receptor-2 pathway has been previously demonstrated to impact endothelial cell survival, we ...
Dimmeler, Stefanie, Gille, Jens, Kaufmann, Roland, Reisinger, Kerstin, Stein, Monika, Urbich, Carmen   +5 more
core   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Particle-based simulation of ellipse-shaped particle aggregation as a model for vascular network formation [PDF]

, 2015
Computational modelling is helpful for elucidating the cellular mechanisms driving biological morphogenesis. Previous simulation studies of blood vessel growth based on the Cellular Potts model (CPM) proposed that elongated, adhesive or mutually attractive endothelial cells suffice for the formation of blood vessel sprouts and vascular networks ...
arxiv   +1 more source

Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. [PDF]

, 2018
In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection.
Hamanaka, Sanae, Hayama, Tomonari, Kasai, Mariko, Kobayashi, Toshihiro, Masaki, Hideki, Mizuno, Naoaki, Nakauchi, Hiromitsu, Sato, Hideyuki, Suchy, Fabian Patrik, Umino, Ayumi, Yamaguchi, Tomoyuki, Yamazaki, Satoshi, Yanagida, Ayaka   +12 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor‐2 gene polymorphisms in patients with gastrointestinal stromal tumors

Asia-Pacific Journal of Clinical Oncology, 2013
AbstractAimThe vascular endothelial growth factor (VEGF) or its family might play role in tumor‐related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor‐2 (VEGFR‐2) gene polymorphisms on the prognosis for GIST patients.MethodsIn all, 213
Wansik Yu, Ho Young Chung, Han Ik Bae, Kyung Hee Lee, Chang Ho Cho, Byung Jo Bae, Mi Jin Gu, Joon Hyuk Choi, Kyun Woo Park, Hong Suk Song, Seung Wan Ryu, Hun Mo Ryoo, Oh Kyoung Kwon, Young Kyung Bae, Hyun Dong Chae, Byung Woog Kang, Yu Na Kang, Yee Soo Chae, Jong Gwang Kim, Se Won Kim   +19 more
openaire   +4 more sources

Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling. [PDF]

, 2010
AIMS: Pre-eclampsia affects 5-7% of pregnancies, and is a major cause of maternal and foetal death. Elevated serum levels of placentally derived splice variants of the vascular endothelial growth factor (VEGF) receptor, soluble fms-like tyrosine kinase-1
Burton, Graham J, Charnock-Jones, D Stephen, Cindrova-Davies, Tereza, Sanders, Deborah A   +3 more
core   +2 more sources