Vascular Endothelial Growth Factor Receptor 3 Signaling Contributes to Angioobliterative Pulmonary Hypertension [PDF]
Pulmonary Circulation, 2015 The mechanisms involved in the development of severe angioobliterative pulmonary arterial hypertension (PAH) are multicellular and complex. Many of the features of human severe PAH, including angioobliteration, lung perivascular inflammation, and right heart failure, are reproduced in the Sugen 5416/chronic hypoxia (SuHx) rat model. Here we address, at
Ayser Al‐Husseini +8 more
openalex +4 more sources
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors [PDF]
Cancer, 1999 Among the molecules important to angiogenesis and lymphangiogenesis is vascular endothelial growth factor receptor 3 (VEGFR-3), a member of the receptor tyrosine kinases of endothelial cells. This receptor is expressed consistently in normal lymphatics, lymphangiomas, and in Kaposi sarcoma, but data regarding other vascular tumors are scant.In this ...
Taina A. Partanen +2 more
openalex +3 more sources
AIP1 Mediates Vascular Endothelial Cell Growth Factor Receptor-3–Dependent Angiogenic and Lymphangiogenic Responses [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Objective— To investigate the novel function of ASK1-interacting protein-1 (AIP1) in vascular endothelial cell growth factor receptor (VEGFR)-3 signaling, and VEGFR-3–dependent angiogenesis and lymphangiogenesis. Approach and Results— AIP1, a signaling scaffold ...
Huanjiao Jenny Zhou +10 more
openalex +3 more sources
Soluble vascular endothelial growth factor receptor-3 suppresses allosensitization and promotes corneal allograft survival [PDF]
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014 To investigate the effect of VEGF-C and VEGF-D blockade via soluble VEGFR-3 (sVEGFR-3) on T cell allosensitization, corneal neovascularization, and transplant survival.Corneal intrastromal suture placement and allogeneic transplantation were performed on BALB/c mice to evaluate the effect of sVEGFR-3 on corneal neovascularization.
Parisa Emami-Naeini +7 more
openalex +4 more sources
Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity [PDF]
Blood, 2013 Key Points Endogenous sVEGFR-3 that is expressed by the cornea binds and sequesters VEGF-C and is critical for corneal alymphaticity. sVEGFR-3 overexpression enhances murine corneal graft transplant survival 5-fold by blocking lymphangiogenesis and hemangiogenesis.
Nirbhai Singh +10 more
openalex +3 more sources
Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice [PDF]
The Korean Journal of Physiology & Pharmacology, 2019 Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and VEGFR-3 was significantly upregulated in the human brains affected with temporal lobe epilepsy.
Kyung‐Ok Cho +4 more
openalex +3 more sources
Vascular Endothelial Growth Factor C/Vascular Endothelial Growth Factor Receptor 3 Signaling Regulates Chemokine Gradients and Lymphocyte Migration From Tissues to Lymphatics [PDF]
Transplantation, 2015 Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide dendritic cells and T cells to lymphatics and then to draining lymph nodes (dLN). Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 (VEGFR-3) are the major lymphatic growth factor
Daiki Iwami +2 more
openalex +3 more sources
Neoplasia, 2012 Mammalian target of rapamycin (mTOR) controls lymphangiogenesis. However, the underlying mechanism is not clear. Here we show that rapamycin suppressed insulin-like growth factor 1 (IGF-1)- or fetal bovine serum (FBS)-stimulated lymphatic endothelial cell (LEC) tube formation, an in vitro model of lymphangiogenesis.
Yan Luo +9 more
openalex +4 more sources
Oncology Reports, 2008 Vascular endothelial growth factor receptor (VEGFR)-3 is a receptor for VEGF-C and D and is implicated in the development of lymphatic vessels and metastasis. The purpose of this study was to investigate the expression of VEGFR-3 and its clinicopathological significance in primary gastric carcinoma (GC).
Ji‐Youn Sung +3 more
openalex +5 more sources
Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis [PDF]
Hepatology, 2007 Hepatitis B x antigen (HBxAg) is a trans -activating protein that contributes to liver cancer, in part, by altering the expression of cellular genes. However,
Zhaorui Lian +6 more
openalex +3 more sources